B Larson1, K Bremme, N Clyne, L Nordström. 1. Departments of Obstetrics and Gynaecology and Nephrology, Karolinska Hospital, Stockholm, and Roche AB, Stockholm, Sweden.
Abstract
AIM: To compare the effects of preoperative treatment with recombinant human erythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemic women prior to hysterectomy. METHODS: The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II). RESULTS: Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups. CONCLUSION: We found that a significantly greater increase in Hb was achieved with iron in combination with EPO, although in most cases iron only seemed to be as efficacious as iron+EPO in correcting anemia in myoma patients pre-operatively.
RCT Entities:
AIM: To compare the effects of preoperative treatment with recombinant humanerythropoietin (EPO) and iron with iron only on hemoglobin levels (Hb) in anemicwomen prior to hysterectomy. METHODS: The study was an open-labelled randomized parallel study. Fifteen women scheduled for hysterectomy due to uterine myoma were given oral iron and EPO (NeoRecormon) 4 weeks prior to surgery (group I) and 16 women were given oral iron only (group II). RESULTS: Group I showed a significantly greater increase in mean Hb during the pre-surgery study period compared with group II (p=0.007). Two weeks postoperatively, however, there was no significant difference in mean Hb between the two groups. CONCLUSION: We found that a significantly greater increase in Hb was achieved with iron in combination with EPO, although in most cases iron only seemed to be as efficacious as iron+EPO in correcting anemia in myomapatients pre-operatively.
Authors: Lutz Kaufner; Christian von Heymann; Anne Henkelmann; Nathan L Pace; Stephanie Weibel; Peter Kranke; Joerg J Meerpohl; Ravi Gill Journal: Cochrane Database Syst Rev Date: 2020-08-13