Literature DB >> 1138022

Globin synthesis in subjects doubly heterozygous for hemoglobin G-Philadelphia and hemoglobin S or C.

P R McCurdy, A S Sherman, H Kamuzora, H Lehmann.   

Abstract

To study the function of globin-chain genes, in vitro synthesis of globin was measured in reticulocytes concentrated from the peripheral blood of 7 subjects doubly heterozygous for an alpha-chain abnormality (Hb G-Philadelphia) and a beta-chain abnormality (Hb S or C). Each had a deficit of alpha-chain synthesis compatible with an alpha-thalassemia-like syndrome. The data are also compatible with the quantitative expression of variable reduplication of the alpha-chain locus in man.

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Year:  1975        PMID： 1138022

Source DB:  PubMed          Journal:  J Lab Clin Med        ISSN： 0022-2143


  3 in total

1.  Trimodality in the proportion of hemoglobin G Philadelphia in heterozygotes: evidence for heterogeneity in the number of human alpha chain loci.

Authors:  R M Baine; D L Rucknagel; P A Dublin; J G Adams
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

2.  Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man.

Authors:  T H Huisman; A Miller
Journal:  Am J Hum Genet       Date:  1976-07       Impact factor: 11.025

3.  Genetic and biosynthetic studies of families carrying hemoglobin J alpha Mexico: association of alpha-thalassemia with HbJ.

Authors:  G Trabuchet; M Benabadji; D Labie
Journal:  Hum Genet       Date:  1978-06-09       Impact factor: 4.132
  3 in total

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