| Literature DB >> 11378364 |
S Cockerill1, C Stubberfield, J Stables, M Carter, S Guntrip, K Smith, S McKeown, R Shaw, P Topley, L Thomsen, K Affleck, A Jowett, D Hayes, M Willson, P Woollard, D Spalding.
Abstract
Described herein is the design and synthesis of indazolylaminopyridopyrimidines and quinazolines as inhibitors of the class 1 tyrosine kinase receptor family. Data is presented for N(4)-(1-benzyl-1H-indazol-5-yl)-N(6),N(6)-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine 3B. This compound inhibited EGFr and c-erbB-2 enzymes selectively over other kinases. It inhibited the proliferation of a range of tumour cell lines in vitro and the growth of BT474 xenografts in SCID mice.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11378364 DOI： 10.1016/s0960-894x(01)00219-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823