| Literature DB >> 11378352 |
H L Sham1, D A Betebenner, T Herrin, G Kumar, A Saldivar, S Vasavanonda, A Molla, D J Kempf, J J Plattner, D W Norbeck.
Abstract
The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined.Entities:
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Year: 2001 PMID： 11378352 DOI： 10.1016/s0960-894x(01)00243-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823