| Literature DB >> 11377238 |
S Padmalatha Rai1, K K Vijayalaxmi.
Abstract
The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0.4 and 0.8 mg/kg b.w. per day. Statistically significant sperm abnormalities revealed the genotoxic potency of this drug.Entities:
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Year: 2001 PMID： 11377238 DOI： 10.1016/s1383-5718(00)00160-1
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433