Literature DB >> 11377173

Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents.

B Jiang1, C G Yang, W N Xiong, J Wang.   

Abstract

Novel indolylpyrimidines and indolylpyrazines have been synthesized as potential antitumor agents. They were screened in a panel of 60 human tumor cell lines in vitro. Compounds 7, 9, 10, 15, 21 exhibited efficiently cytotoxic activities with GI(50) values in the low micromolar range against a variety of human cancer cell lines. 2,4-Bis(3'-indolyl)pyrimidine 8 displayed selective cytotoxic activity against IGROV1 tumor cell line with the GI(50) value below 0.01 microM.

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Year:  2001        PMID： 11377173     DOI： 10.1016/s0968-0896(00)00337-0

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Investigation of rotameric conformations of substituted imidazo-[1,2-a]pyrazine: experimental and theoretical approaches.

Authors:  Gulshan Kumar; Richa Goel; Kamaldeep Paul; Vijay Luxami
Journal:  RSC Adv       Date:  2018-03-07       Impact factor: 4.036

2.  Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives.

Authors:  Pallabi Borah; P Seetham Naidu; Swarup Majumder; Pulak J Bhuyan
Journal:  Mol Divers       Date:  2014-07-11       Impact factor: 2.943

3.  Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues.

Authors:  Anna Carbone; Barbara Parrino; Gloria Di Vita; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-01-16       Impact factor: 5.118

4.  3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.

Authors:  Barbara Parrino; Anna Carbone; Gloria Di Vita; Cristina Ciancimino; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118

Review 5.  Nitroketene N,S-acetals: synergistic building blocks for the synthesis of heterocycles.

Authors:  Sarfaraz Khan; Habibur Rahman; Md Musawwer Khan
Journal:  RSC Adv       Date:  2019-05-09       Impact factor: 4.036

6.  Retracted Article: The synthesis and biological activity of marine alkaloid derivatives and analogues.

Authors:  Shiyang Zhou; Gangliang Huang
Journal:  RSC Adv       Date:  2020-08-28       Impact factor: 4.036

7.  Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.

Authors:  Piyush Kumar Agarwal; Meena Devi Dathi; Mohammad Saifuddin; Bijoy Kundu
Journal:  Beilstein J Org Chem       Date:  2012-11-08       Impact factor: 2.883

8.  Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.

Authors:  Anna Carbone; Barbara Parrino; Paola Barraja; Virginia Spanò; Girolamo Cirrincione; Patrizia Diana; Armin Maier; Gerhard Kelter; Heinz-Herbert Fiebig
Journal:  Mar Drugs       Date:  2013-03-01       Impact factor: 5.118
  8 in total

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