BACKGROUND: Elderly people who develop depression have demonstrable changes in cerebral structure but little is known of the relationship between regional cerebral volumes, treatment response and cognitive impairment. METHOD: Forty-four patients with major depression diagnosed according to DSM-IIIR criteria underwent magnetic resonance imaging and regional cerebral volumes were quantified using multispectral analysis. Response to antidepressant treatment was assessed prospectively and a neuropsychological test battery was administered. RESULTS: There was a trend for smaller fronto-temporal volumes in the treatment-resistant patients. Impaired immediate working memory was linked with reduced frontal and parietal lobe volume and impaired short-term memory functioning was associated with reduced temporal lobe volume. Ventricular enlargement was associated with prior administration of electro-convulsive therapy, poor physical health and later age at onset of first episode of depression. CONCLUSION: In late-life depression, brain changes should not preclude vigorous antidepressant treatment. Regional cerebral volume changes may be a complication of poor physical health and are associated with memory dysfunction even upon recovery from depression. Copyright 2001 John Wiley & Sons, Ltd
BACKGROUND: Elderly people who develop depression have demonstrable changes in cerebral structure but little is known of the relationship between regional cerebral volumes, treatment response and cognitive impairment. METHOD: Forty-four patients with major depression diagnosed according to DSM-IIIR criteria underwent magnetic resonance imaging and regional cerebral volumes were quantified using multispectral analysis. Response to antidepressant treatment was assessed prospectively and a neuropsychological test battery was administered. RESULTS: There was a trend for smaller fronto-temporal volumes in the treatment-resistant patients. Impaired immediate working memory was linked with reduced frontal and parietal lobe volume and impaired short-term memory functioning was associated with reduced temporal lobe volume. Ventricular enlargement was associated with prior administration of electro-convulsive therapy, poor physical health and later age at onset of first episode of depression. CONCLUSION: In late-life depression, brain changes should not preclude vigorous antidepressant treatment. Regional cerebral volume changes may be a complication of poor physical health and are associated with memory dysfunction even upon recovery from depression. Copyright 2001 John Wiley & Sons, Ltd
Authors: Deanna M Barch; Gina DʼAngelo; Carl Pieper; Consuelo H Wilkins; Kathleen Welsh-Bohmer; Warren Taylor; Keith S Garcia; Kenneth Gersing; P Murali Doraiswamy; Yvette I Sheline Journal: Am J Geriatr Psychiatry Date: 2012-08 Impact factor: 4.105
Authors: P Cédric M P Koolschijn; Neeltje E M van Haren; Gerty J L M Lensvelt-Mulders; Hilleke E Hulshoff Pol; René S Kahn Journal: Hum Brain Mapp Date: 2009-11 Impact factor: 5.038
Authors: Dolores Gallagher Thompson; Shelli R Kesler; Keith Sudheimer; Kala Mehendra Mehta; Larry W Thompson; Renee M Marquett; Jason M Holland; Robert Reiser; Natalie Rasgon; Alan Schatzberg; Ruth M O'Hara Journal: Am J Geriatr Psychiatry Date: 2014-02-18 Impact factor: 4.105
Authors: Vishal Bali; Michael L Johnson; Hua Chen; Marc L Fleming; Holly M Holmes; Rajender R Aparasu Journal: Ann Pharmacother Date: 2015-11-25 Impact factor: 3.154