Literature DB >> 11375739

Identification of inhibitors of DNA topoisomerase II from a synthetic library of glycoconjugates.

R P Tripathi1, S K Rastogi, B Kundu, J K Saxena, V J Reddy, S Srivastava, S Chandra, A P Bhaduri.   

Abstract

A library of 24 glycoconjugates related to glycosylated beta-amino acid derivative (I) was been prepared and screened against DNA topoisomerase-II of the filarial parasite S. cervi. Among these, compound 6 was found to be a potent inhibitor of DNA topoisomerase-II with 95% inhibition at 1.09 microM. Furthermore, compound 6 was at least three times more potent than the lead compound, glycosylated beta-amino acid derivative I.

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Year:  2001        PMID： 11375739     DOI： 10.2174/1386207013331084

Source DB:  PubMed          Journal:  Comb Chem High Throughput Screen        ISSN： 1386-2073            Impact factor:   1.339


  1 in total

1.  Combinatorial synthesis of unsymmetrical secondary amines. Application to arylethanolamines, arylpropanolamines and aryloxypropanolamines.

Authors:  S K Rastogi; P Gupta; T Srinivasan; B Kundu
Journal:  Mol Divers       Date:  2000       Impact factor: 2.943
  1 in total

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