Literature DB >> 11374978

Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

S Y Kang1, K Y Lee, S H Sung, M J Park, Y C Kim.   

Abstract

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

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Year:  2001        PMID: 11374978     DOI: 10.1021/np000441w

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  19 in total

1.  Tuning the Lewis acid phenol ortho-prenylation as a molecular diversity tool.

Authors:  Sebastián N Jäger; Exequiel O J Porta; Guillermo R Labadie
Journal:  Mol Divers       Date:  2015-11-03       Impact factor: 2.943

Review 2.  Enantiomeric natural products: occurrence and biogenesis.

Authors:  Jennifer M Finefield; David H Sherman; Martin Kreitman; Robert M Williams
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-03       Impact factor: 15.336

3.  Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.

Authors:  Tae Hun Lee; Joon Ha Park; Jong-Dai Kim; Jae-Chul Lee; In Hye Kim; Yongbae Yim; Seul Ki Lee; Bing Chun Yan; Ji Hyeon Ahn; Choong Hyun Lee; Ki-Yeon Yoo; Jung Hoon Choi; In Koo Hwang; Jeong Ho Park; Moo-Ho Won
Journal:  Cell Mol Neurobiol       Date:  2012-07-20       Impact factor: 5.046

4.  Pilot-scale subcritical-water extraction of nodakenin and decursin from Angelica gigas Nakai.

Authors:  Min-Jung Ko; Mi-Ri Kwon; Myong-Soo Chung
Journal:  Food Sci Biotechnol       Date:  2019-11-28       Impact factor: 2.391

5.  Cancer Chemoprevention with Korean Angelica: Active Compounds, Pharmacokinetics, and Human Translational Considerations.

Authors:  Junxuan Lü; Jinhui Zhang; Li Li; Cheng Jiang; Chengguo Xing
Journal:  Curr Pharmacol Rep       Date:  2015-04-19

6.  Anticholinesterase activity of endemic plant extracts from Soqotra.

Authors:  Hussein Bakthira; Nasser A Awadh Ali; Norbert Arnold; Axel Teichert; Ludger Wessjohann
Journal:  Afr J Tradit Complement Altern Med       Date:  2011-04-02

7.  Strategies for the Preparation of Differentially Protected ortho-Prenylated Phenols.

Authors:  Christophe Hoarau; Thomas R R Pettus
Journal:  Synlett       Date:  2003       Impact factor: 2.454

8.  Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes.

Authors:  Kwan Joong Kim; Young Sung Jung; Dong Min You; Seung Hyun Lee; Guemsan Lee; Kang-Beom Kwon; Dae-Ok Kim
Journal:  Food Sci Biotechnol       Date:  2021-02-05       Impact factor: 2.391

9.  Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.

Authors:  Bing Chun Yan; Joon Ha Park; Bich Na Shin; Ji Hyeon Ahn; In Hye Kim; Jae-Chul Lee; Ki-Yeon Yoo; In Koo Hwang; Jung Hoon Choi; Jeong Ho Park; Yun Lyul Lee; Hong-Won Suh; Jong-Gab Jun; Young-Guen Kwon; Young-Myeong Kim; Seung-Hae Kwon; Song Her; Jin Su Kim; Byung-Hwa Hyun; Chul-Kyu Kim; Jun Hwi Cho; Choong Hyun Lee; Moo-Ho Won
Journal:  PLoS One       Date:  2013-09-20       Impact factor: 3.240

10.  Rutamarin: Efficient Liquid-Liquid Chromatographic Isolation from Ruta graveolens L. and Evaluation of Its In Vitro and In Silico MAO-B Inhibitory Activity.

Authors:  Ewelina Kozioł; Simon Vlad Luca; Hale Gamze Ağalar; Begüm Nurpelin Sağlık; Fatih Demirci; Laurence Marcourt; Jean-Luc Wolfender; Krzysztof Jóźwiak; Krystyna Skalicka-Woźniak
Journal:  Molecules       Date:  2020-06-09       Impact factor: 4.411

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