Literature DB >> 1137362

Isolation and characterization of a gamma-thiochromanone-4-thiosemicarbazone-resistant mutant of vaccinia virus.

E Katz, E Margalith, B Winer.   

Abstract

gamma-Thiochromanone-4-thiosemicarbazone (TCT) inhibits the growth of vaccinia virus in BSCl cells by interfering with viral maturation. A mutant of the virus (TCT(R)) which is resistant to this drug was isolated. This mutant also exhibits resistance to another thiosemicarbazone related compound, isatin beta-thiosemicarbazone (IBT). There is a good correlation between the cross-resistance of the two mutants IBT(R) and TCT(R) to TCT and IBT, respectively, and the similar antipoxvirus activity of these two thiosemicarbazone-related compounds.

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Year:  1975        PMID： 1137362      PMCID： PMC429078          DOI： 10.1128/AAC.7.1.85

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

2.  ACTINOMYCIN D AND VACCINIA VIRUS INFECTION OF HELA CELLS.

Authors:  A J SHATKIN
Journal:  Nature       Date:  1963-07-27       Impact factor: 49.962

3.  THE REPLICATION AND COATING OF VACCINIA DNA.

Authors:  W K JOKLIK; Y BECKER
Journal:  J Mol Biol       Date:  1964-12       Impact factor: 5.469

4.  Anti-vaccinia activity of -thiochromanone-1-thiosemicarbazone in vitro and in vivo.

Authors:  A Tsunoda; K Miyazaki; T Aota; S Matsumoto; K Kumagai
Journal:  Jpn J Microbiol       Date:  1972-01

5.  Sequential protein synthesis following vaccinia virus infection.

Authors:  B Moss; N P Salzman
Journal:  J Virol       Date:  1968-10       Impact factor: 5.103

6.  Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.

Authors:  D F Summers; J V Maizel; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1965-08       Impact factor: 11.205

7.  Isolation and characterization of an IBT-dependent mutant of vaccinia virus.

Authors:  E Katz; B Winer; E Margalith; N Goldblum
Journal:  J Gen Virol       Date:  1973-04       Impact factor: 3.891

8.  Sequential formation of vaccinia virus proteins and viral deoxyribonucleic acid replication.

Authors:  N P Salzman; E D Sebring
Journal:  J Virol       Date:  1967-02       Impact factor: 5.103

9.  Vaccinia virus structural polypeptide derived from a high-molecular-weight precursor: formation and integration into virus particles.

Authors:  E Katz; B Moss
Journal:  J Virol       Date:  1970-12       Impact factor: 5.103

10.  The rate of formation of vaccinia deoxyribonucleic acid and vaccinia virus.

Authors:  N P SALZMAN
Journal:  Virology       Date:  1960-01       Impact factor: 3.616
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