J Deng1, X Liu, Y Liu. 1. Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120, China.
Abstract
OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.
OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.