OBJECTIVE: The aim of this study was to define the role of surgery in managing patients with a primary squamous vaginal cancer. METHODS: A retrospective review was conducted of patients with primary invasive vaginal cancer managed at one institution over a 25-year period. The results were compared with those of all major publications of the past 20 years. RESULTS: A total of 84 patients were reviewed. Forty-five (66%) were of squamous origin. The median follow-up was 45 months (range: 0.6-268). The patients were primarily treated by surgery in 67% and by radiotherapy alone in 33% of cases. The 5- and 10-year overall survival was, respectively, 74 and 58%. For stage I the figures were 91 and 70%. These survival rates compared favorably with those of published series of cases managed by radiotherapy alone. Univariate analysis showed that age (P = 0.004), size (P = 0.009), site (P = 0.016), lymph node status (P = 0.022), FIGO stage (P = 0.027), and treatment (P = 0.003) were relevant prognostic factors. Multiple regression analysis, however, revealed that only age (P = 0.009) and size (P = 0.037) were independent prognostic variables. CONCLUSIONS: Stage I and II squamous vaginal cancer patients have good outcomes in terms of survival and local tumor control if they are managed by initial surgery followed by selective radiotherapy. Copyright 2001 Academic Press.
OBJECTIVE: The aim of this study was to define the role of surgery in managing patients with a primary squamous vaginal cancer. METHODS: A retrospective review was conducted of patients with primary invasive vaginal cancer managed at one institution over a 25-year period. The results were compared with those of all major publications of the past 20 years. RESULTS: A total of 84 patients were reviewed. Forty-five (66%) were of squamous origin. The median follow-up was 45 months (range: 0.6-268). The patients were primarily treated by surgery in 67% and by radiotherapy alone in 33% of cases. The 5- and 10-year overall survival was, respectively, 74 and 58%. For stage I the figures were 91 and 70%. These survival rates compared favorably with those of published series of cases managed by radiotherapy alone. Univariate analysis showed that age (P = 0.004), size (P = 0.009), site (P = 0.016), lymph node status (P = 0.022), FIGO stage (P = 0.027), and treatment (P = 0.003) were relevant prognostic factors. Multiple regression analysis, however, revealed that only age (P = 0.009) and size (P = 0.037) were independent prognostic variables. CONCLUSIONS: Stage I and II squamous vaginal cancerpatients have good outcomes in terms of survival and local tumor control if they are managed by initial surgery followed by selective radiotherapy. Copyright 2001 Academic Press.
Authors: C S Gardner; J Sunil; A H Klopp; C E Devine; T Sagebiel; C Viswanathan; P R Bhosale Journal: Br J Radiol Date: 2015-05-12 Impact factor: 3.039
Authors: Hans-Georg Schnürch; Sven Ackermann; Celine D Alt-Radtke; Lukas Angleitner; Jana Barinoff; Matthias W Beckmann; Carsten Böing; Christian Dannecker; Tanja Fehm; Rüdiger Gaase; Paul Gass; Marion Gebhardt; Friederike Gieseking; Andreas Günthert; Carolin C Hack; Peer Hantschmann; Lars Christian Horn; Martin C Koch; Anne Letsch; Peter Mallmann; Bernhard Mangold; Simone Marnitz; Grit Mehlhorn; Kerstin Paradies; Michael J Reinhardt; Reina Tholen; Uwe Torsten; Wolfgang Weikel; Linn Wölber; Monika Hampl Journal: Geburtshilfe Frauenheilkd Date: 2019-07-16 Impact factor: 2.915
Authors: Jeremy S Blum; Caroline E Weller; Carmen J Booth; Imran A Babar; Xianping Liang; Frank J Slack; W Mark Saltzman Journal: Drug Deliv Transl Res Date: 2011-10-01 Impact factor: 4.617
Authors: Said Ait Laalim; Imane Tourghai; Karim Ibnmejdoub; Khalid Mazaz; Sanaa Raghy; Leila Chbani; El Mazghi Abderahman; Fatim Zahra Hijri Journal: Pan Afr Med J Date: 2013-05-21
Authors: Steffi van Wessel; Helena Van Kerrebroeck; Valerie Van Bogaert; Philippe Tummers; Rudy Van den Broecke Journal: Gynecol Oncol Case Rep Date: 2013-01-29