BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo.
BACKGROUND:Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo.
Authors: Ana Mo Miranda; Thiago M Ferrari; Juliana T Werneck; Arley Silva Junior; Karin S Cunha; Eliane P Dias Journal: World J Clin Cases Date: 2014-08-16 Impact factor: 1.337
Authors: Juan Carlos Cuevas-Gonzalez; Zahide Lievanos-Estrada; Maria Elisa Vega-Memije; Maria Teresa Hojyo-Tomoka; Luciano Dominguez-Soto Journal: An Bras Dermatol Date: 2016 Jan-Feb Impact factor: 1.896
Authors: Juan Carlos Cuevas-Gonzalez; María Elisa Vega-Memíje; Socorro Aída Borges-Yáñez; Erika Rodríguez-Lobato Journal: An Bras Dermatol Date: 2017 Nov-Dec Impact factor: 1.896