Literature DB >> 1136966

Treatment of acute isoniazid toxicity.

M L Sievers, R N Herrier.   

Abstract

The clinical symptoms and treatment of acute isoniazid toxicity are presented. The use of supportive measures and chemotherapy are discussed in detail. The pharmacology and biochemistry underlying the symptons of isoniazid poisoning are aslo presented. It is concluded that diazepam in combination with pyridoxine is the treatment of choice for the management of convulsions associated with isoniazid toxicity. Pyridoxine should be administered intravenously in amounts equal to the estimated quantity of isoniazid ingested, even if seizures have not occurred.

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Year:  1975        PMID： 1136966

Source DB:  PubMed          Journal:  Am J Hosp Pharm        ISSN： 0002-9289


  11 in total

Review 1.  [Central nervous system side effects of different antibacterial substances].

Authors:  G Stoppe; E Rüther
Journal:  Infection       Date:  1991       Impact factor: 3.553

2.  Isoniazid overdose. Successful treatment with pyridoxine and hemodialysis.

Authors:  J M Cash; E T Zawada
Journal:  West J Med       Date:  1991-12

Review 3.  Clinical features, pathogenesis and management of drug-induced seizures.

Authors:  G Zaccara; G C Muscas; A Messori
Journal:  Drug Saf       Date:  1990 Mar-Apr       Impact factor: 5.606

Review 4.  Clinical applications of commonly used contemporary antidotes. A US perspective.

Authors:  C A Bowden; E P Krenzelok
Journal:  Drug Saf       Date:  1997-01       Impact factor: 5.606

5.  Toxic overdose of isoniazid, rifampicin and ethambutol.

Authors:  C T Spalding; W C Buss
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

6.  The effects of isoniazid on hippocampal NMDA receptors: protective role of erdosteine.

Authors:  Ekrem Cicek; Recep Sutcu; Osman Gokalp; H Ramazan Yilmaz; M Kaya Ozer; Efkan Uz; Nurten Ozcelik; Namik Delibas
Journal:  Mol Cell Biochem       Date:  2005-09       Impact factor: 3.396

Review 7.  Neurological manifestations and toxicities of the antituberculosis drugs. A review.

Authors:  M R Holdiness
Journal:  Med Toxicol       Date:  1987 Jan-Feb

Review 8.  Isoniazid overdose: four case reports and review of the literature.

Authors:  F G Alvarez; K K Guntupalli
Journal:  Intensive Care Med       Date:  1995-08       Impact factor: 17.440

9.  Isoniazid toxicity presenting as seizures and metabolic acidosis.

Authors:  R C Watkins; E L Hambrick; G Benjamin; S N Chavda
Journal:  J Natl Med Assoc       Date:  1990-01       Impact factor: 1.798

10.  Isoniazid overdose : a case series, literature review and survey of antidote availability.

Authors:  Graeme Maw; Peter Aitken
Journal:  Clin Drug Investig       Date:  2003       Impact factor: 2.859
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