BACKGROUND: Although it was reported that pulse pressure of the peripheral artery could differentiate patients with coronary heart disease (CHD) from those without CHD, it is not known whether pulsatility of the ascending aortic pressure waveform differentiates patients with CHD from those without CHD. The purpose of this study was to evaluate whether the pulsatility of ascending aortic pressure is associated with an increased risk of CHD. METHODS: For this study, we enrolled 293 subjects who had chest pain, normal contractions, no local asynergy, and no history of myocardial infarction. We measured the ascending aortic pressure using a fluid-filled system. To quantify the relative magnitude of the pulsatile to mean artery pressure, we normalized the pulse pressure to the mean pressure and referred to this value as the fractional pulse pressure (PPf). We investigated the association between the PPf and the risk of CHD. RESULTS: The PPf of the ascending aorta was associated with an increased risk of CHD. The multiple-adjusted odds ratio of CHD was 2.93 (95% CI, 1.44 to 5.94) for the middle tertile of the PPf level and was 3.93 (95% CI, 1.74 to 8.85) for the highest tertile compared with the lowest tertile. CONCLUSION: Ascending aortic pulsatility is related to an increased risk of CHD.
BACKGROUND: Although it was reported that pulse pressure of the peripheral artery could differentiate patients with coronary heart disease (CHD) from those without CHD, it is not known whether pulsatility of the ascending aortic pressure waveform differentiates patients with CHD from those without CHD. The purpose of this study was to evaluate whether the pulsatility of ascending aortic pressure is associated with an increased risk of CHD. METHODS: For this study, we enrolled 293 subjects who had chest pain, normal contractions, no local asynergy, and no history of myocardial infarction. We measured the ascending aortic pressure using a fluid-filled system. To quantify the relative magnitude of the pulsatile to mean artery pressure, we normalized the pulse pressure to the mean pressure and referred to this value as the fractional pulse pressure (PPf). We investigated the association between the PPf and the risk of CHD. RESULTS: The PPf of the ascending aorta was associated with an increased risk of CHD. The multiple-adjusted odds ratio of CHD was 2.93 (95% CI, 1.44 to 5.94) for the middle tertile of the PPf level and was 3.93 (95% CI, 1.74 to 8.85) for the highest tertile compared with the lowest tertile. CONCLUSION: Ascending aortic pulsatility is related to an increased risk of CHD.
Authors: Georges Khoueiry; Basem Azab; Estelle Torbey; Nidal Abi Rafeh; Jean-Paul Atallah; Kathleen Ahern; James Malpeso; Donald McCord; Elie R Chemaly Journal: Am J Hypertens Date: 2012-06-28 Impact factor: 2.689
Authors: Gailing Chen; Kevin P Bliden; Rahul Chaudhary; Fang Liu; Himabindu Kaza; Eliano P Navarese; Udaya S Tantry; Paul A Gurbel Journal: J Thromb Thrombolysis Date: 2017-08 Impact factor: 2.300
Authors: S Wassertheurer; J Kropf; T Weber; M van der Giet; J Baulmann; M Ammer; B Hametner; C C Mayer; B Eber; D Magometschnigg Journal: J Hum Hypertens Date: 2010-03-18 Impact factor: 3.012
Authors: Yusuf I Alihanoglu; Mehmet Kayrak; Mehmet S Ulgen; Mehmet Yazici; Mehmet Yazici; Remzi Yilmaz; Kenan Demir; Yildiz Dogan; Murat Sizer; Hakan Ozhan; Fatih Koc; Sait Bodur Journal: J Clin Hypertens (Greenwich) Date: 2013-07-16 Impact factor: 3.738