| Literature DB >> 11367871 |
S Mavel1, J L Renou, C Galtier, R Snoeck, G Andrei, J Balzarini, E De Clercq, A Gueiffier.
Abstract
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.Entities:
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Year: 2001 PMID： 11367871 DOI： 10.1055/s-0031-1300042
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172