OBJECTIVE: To determine whether specific viruses are associated with HIV infection in Tanzanian children with chronic diarrhea. DESIGN: Cross-sectional survey. SETTING: Major national teaching hospital in Dar es Salaam, Tanzania. PATIENTS: Consecutively admitted, human immunodeficiency virus (HIV)-infected and HIV-uninfected children with chronic diarrhea, and controls without diarrhea, aged 15 months to 5 years. MAIN OUTCOME MEASURE: Enteric viruses identified by electron microscopy (EM) of fecal specimens. RESULTS: Small round structured viruses (SRSV) were more frequent in HIV-infected than HIV-uninfected children with chronic diarrhea (4 of 21 vs 1 of 32, prevalence ratio = 6.09, 90% confidence limits 1.03, 36.14). Rotavirus and coronavirus-like particles (CVLP) were not associated with HIV infection. CONCLUSION: SRSV may be associated with HIV infection in Tanzanian children with chronic diarrhea. Larger, confirmatory studies are needed.
OBJECTIVE: To determine whether specific viruses are associated with HIV infection in Tanzanian children with chronic diarrhea. DESIGN: Cross-sectional survey. SETTING: Major national teaching hospital in Dar es Salaam, Tanzania. PATIENTS: Consecutively admitted, human immunodeficiency virus (HIV)-infected and HIV-uninfectedchildren with chronic diarrhea, and controls without diarrhea, aged 15 months to 5 years. MAIN OUTCOME MEASURE: Enteric viruses identified by electron microscopy (EM) of fecal specimens. RESULTS: Small round structured viruses (SRSV) were more frequent in HIV-infected than HIV-uninfectedchildren with chronic diarrhea (4 of 21 vs 1 of 32, prevalence ratio = 6.09, 90% confidence limits 1.03, 36.14). Rotavirus and coronavirus-like particles (CVLP) were not associated with HIV infection. CONCLUSION:SRSV may be associated with HIV infection in Tanzanian children with chronic diarrhea. Larger, confirmatory studies are needed.
Authors: N A Page; M J Groome; S Nadan; R Netshikweta; K H Keddy; B Poonsamy; J Moyes; S Walaza; K Kahn; S A Madhi; M B Taylor; J Mans; C Cohen Journal: Epidemiol Infect Date: 2017-04-10 Impact factor: 4.434
Authors: Syed A Sattar; V Susan Springthorpe; Jason Tetro; Robert Vashon; Bruce Keswick Journal: Am J Infect Control Date: 2002-10 Impact factor: 2.918