D D Gladman1, E N Hing, C T Schentag, R J Cook. 1. University of Toronto Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada.
Abstract
OBJECTIVE: To determine the frequency of remission in psoriatic arthritis (PsA), to describe the characteristics of remission in PsA, and to identify features associated with remission in PsA. METHODS: Patients with PsA are followed prospectively according to a standard protocol. Only patients with > or =3 visits and those with peripheral arthritis were included in this study. Patients who sustained remission, defined as no actively inflamed joints on at least 3 consecutive visits, were compared to patients with persistent inflammation throughout the followup period (nonremission). RESULTS: Among 391 patients with peripheral arthritis and > or =3 visits, 69 patients sustained remission and 178 had persistent inflammatory activity. The frequency of remission was thus 17.6%. The average duration of remission was 2.6 years. However, 52% of the patients experienced flare after a mean of 1.8 years. Univariate analyses revealed that male sex, fewer actively inflamed and damaged joints, and better functional class at presentation to clinic were associated with remission. CONCLUSION: Remission does occur in PsA and may be prolonged. There are clinical characteristics of patients at their first clinic visit that are associated with future remission.
OBJECTIVE: To determine the frequency of remission in psoriatic arthritis (PsA), to describe the characteristics of remission in PsA, and to identify features associated with remission in PsA. METHODS:Patients with PsA are followed prospectively according to a standard protocol. Only patients with > or =3 visits and those with peripheral arthritis were included in this study. Patients who sustained remission, defined as no actively inflamed joints on at least 3 consecutive visits, were compared to patients with persistent inflammation throughout the followup period (nonremission). RESULTS: Among 391 patients with peripheral arthritis and > or =3 visits, 69 patients sustained remission and 178 had persistent inflammatory activity. The frequency of remission was thus 17.6%. The average duration of remission was 2.6 years. However, 52% of the patients experienced flare after a mean of 1.8 years. Univariate analyses revealed that male sex, fewer actively inflamed and damaged joints, and better functional class at presentation to clinic were associated with remission. CONCLUSION: Remission does occur in PsA and may be prolonged. There are clinical characteristics of patients at their first clinic visit that are associated with future remission.
Authors: Franak M Batliwalla; Wentian Li; Christopher T Ritchlin; Xiangli Xiao; Max Brenner; Teresina Laragione; Tianmeng Shao; Robert Durham; Sunil Kemshetti; Edward Schwarz; Rodney Coe; Marlena Kern; Emily C Baechler; Timothy W Behrens; Peter K Gregersen; Pércio S Gulko Journal: Mol Med Date: 2005 Jan-Dec Impact factor: 6.354
Authors: Rina Mina; Marisa S Klein-Gitelman; Angelo Ravelli; Michael W Beresford; Tadej Avcin; Graciela Espada; B Anne Eberhard; Laura E Schanberg; Kathleen M O'Neil; Clovis A Silva; Gloria C Higgins; Karen Onel; Nora G Singer; Emily von Scheven; Lisa F Imundo; Shannen Nelson; Edward H Giannini; Hermine I Brunner Journal: Arthritis Care Res (Hoboken) Date: 2012-05 Impact factor: 4.794
Authors: M L Acosta Felquer; L Ferreyra Garrott; J Marin; E Catay; M Scolnik; V Scaglioni; S Ruta; J Rosa; E R Soriano Journal: Clin Rheumatol Date: 2014-05-13 Impact factor: 2.980