B K Abraham1, C Adithan, P U Kiran, M Asad, K Koumaravelou. 1. Clinical Pharmacology Unit, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India.
Abstract
AIM: To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Karnataka (KA) and Andhra Pradesh (AP) population. METHODS: Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan (DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping. RESULTS: The prevalence of poor metabolisers (PM) in KA is 4% and AP is 1.8%. CONCLUSION: The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.
AIM: To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Karnataka (KA) and Andhra Pradesh (AP) population. METHODS: Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan (DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping. RESULTS: The prevalence of poor metabolisers (PM) in KA is 4% and AP is 1.8%. CONCLUSION: The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.
Authors: B K Abraham; C Adithan; J Mohanasundaram; C H Shashindran; K Koumaravelou; M Asad Journal: Eur J Clin Pharmacol Date: 2001 Jan-Feb Impact factor: 2.953
Authors: C Adithan; N Gerard; A T Naveen; K Koumaravelou; C H Shashindran; R Krishnamoorthy Journal: Eur J Clin Pharmacol Date: 2003-08-27 Impact factor: 2.953