Y Zhang1, N Zhong, Z N Zhou. 1. Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China.
Abstract
AIM: To study the effects of estradiol (Est) on antiarrhythmic and antioxidative effects of intermittent hypoxia in rat heart. METHODS: Ligating and loosening the coronary artery of rat to induce ischemic and reperfusion arrhythmias, using arrhythmia score (AS) to evaluate the arrhythmias, measuring the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in myocardium. RESULTS: AS of arrhythmia induced by ischemia and reperfusion in intermittent hypoxia 28-d group (IH28) and in intermittent hypoxia with Est group (IH14-Est) are lower than that in control group (CON), respectively. AS of ischemic arrhythmia but not reperfusion arrhythmia in Est treated group (ESTG) was lower than that in CON. No significant difference in AS of ischemia and reperfusion existed among CON, vehicle group (VEH), and intermittent hypoxia 14-d group (IH14). The activity of SOD was higher and the content of MDA was lower in IH28 and in IH14-Est compared with that in CON. No significant difference of the activity of SOD and the content of MDA existed among CON, VEH, IH14, and ESTG. CONCLUSION: Est potentiated the antiarrhythmic and antioxidative effects of intermittent hypoxia on rat heart.
AIM: To study the effects of estradiol (Est) on antiarrhythmic and antioxidative effects of intermittent hypoxia in rat heart. METHODS: Ligating and loosening the coronary artery of rat to induce ischemic and reperfusion arrhythmias, using arrhythmia score (AS) to evaluate the arrhythmias, measuring the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in myocardium. RESULTS: AS of arrhythmia induced by ischemia and reperfusion in intermittent hypoxia 28-d group (IH28) and in intermittent hypoxia with Est group (IH14-Est) are lower than that in control group (CON), respectively. AS of ischemic arrhythmia but not reperfusion arrhythmia in Est treated group (ESTG) was lower than that in CON. No significant difference in AS of ischemia and reperfusion existed among CON, vehicle group (VEH), and intermittent hypoxia 14-d group (IH14). The activity of SOD was higher and the content of MDA was lower in IH28 and in IH14-Est compared with that in CON. No significant difference of the activity of SOD and the content of MDA existed among CON, VEH, IH14, and ESTG. CONCLUSION: Est potentiated the antiarrhythmic and antioxidative effects of intermittent hypoxia on rat heart.
Authors: Robert T Mallet; Eugenia B Manukhina; Steven Shea Ruelas; James L Caffrey; H Fred Downey Journal: Am J Physiol Heart Circ Physiol Date: 2018-04-13 Impact factor: 4.733
Authors: Jana Kohutova; Barbara Elsnicova; Kristyna Holzerova; Jan Neckar; Ondrej Sebesta; Jana Jezkova; Marek Vecka; Pavel Vebr; Daniela Hornikova; Barbara Szeiffova Bacova; Tamara Egan Benova; Marketa Hlavackova; Narcis Tribulova; Frantisek Kolar; Olga Novakova; Jitka M Zurmanova Journal: Front Endocrinol (Lausanne) Date: 2019-01-25 Impact factor: 5.555