Literature DB >> 11359722

T1 hypointensities and axonal loss.

F Barkhof1, G B Karas, M A van Walderveen.   

Abstract

T1 hypointensities are lesions that are hypointense on moderately T1-weighted conventional spin-echo sequences and serve as markers of matrix destruction and axonal loss. They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials.

Entities:  

Mesh：

Year:  2000        PMID： 11359722

Source DB:  PubMed          Journal:  Neuroimaging Clin N Am        ISSN： 1052-5149            Impact factor:   2.264


  16 in total

1.  Use of Magnetic Resonance Imaging as Well as Clinical Disease Activity in the Clinical Classification of Multiple Sclerosis and Assessment of Its Course: A Report from an International CMSC Consensus Conference, March 5-7, 2010.

Authors:  Stuart D Cook; Suhayl Dhib-Jalbut; Peter Dowling; Luca Durelli; Corey Ford; Gavin Giovannoni; June Halper; Colleen Harris; Joseph Herbert; David Li; John A Lincoln; Robert Lisak; Fred D Lublin; Claudia F Lucchinetti; Wayne Moore; Robert T Naismith; Carlos Oehninger; Jack Simon; Maria Pia Sormani
Journal:  Int J MS Care       Date:  2012

2.  Effect of glatiramer acetate three-times weekly on the evolution of new, active multiple sclerosis lesions into T1-hypointense "black holes": a post hoc magnetic resonance imaging analysis.

Authors:  Robert Zivadinov; Michael Dwyer; Hadas Barkay; Joshua R Steinerman; Volker Knappertz; Omar Khan
Journal:  J Neurol       Date:  2014-12-27       Impact factor: 4.849

3.  Chronic T2 Lesions in Multiple Sclerosis are Heterogeneous Regarding Phase MR Imaging.

Authors:  S Siemonsen; K L Young; M Bester; J Sedlacik; C Heesen; J Fiehler; J-P Stellmann
Journal:  Clin Neuroradiol       Date:  2015-04-18       Impact factor: 3.649

Review 4.  Multiple sclerosis update: use of MRI for early diagnosis, disease monitoring and assessment of treatment related complications.

Authors:  Mark S Igra; David Paling; Mike P Wattjes; Daniel J A Connolly; Nigel Hoggard
Journal:  Br J Radiol       Date:  2017-04-26       Impact factor: 3.039

5.  Intensity ratio to improve black hole assessment in multiple sclerosis.

Authors:  Gautam Adusumilli; Kathryn Trinkaus; Peng Sun; Samantha Lancia; Jeffrey D Viox; Jie Wen; Robert T Naismith; Anne H Cross
Journal:  Mult Scler Relat Disord       Date:  2017-12-02       Impact factor: 4.339

Review 6.  The Relevance of Neuroimaging Findings to Physical Disability in Multiple Sclerosis.

Authors:  Rahşan Göçmen
Journal:  Noro Psikiyatr Ars       Date:  2018       Impact factor: 1.339

7.  MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability.

Authors:  D S Meier; H L Weiner; C R G Guttmann
Journal:  AJNR Am J Neuroradiol       Date:  2007 Nov-Dec       Impact factor: 3.825

8.  Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis.

Authors:  Belinda S Y Li; Juleiga Regal; Brian J Soher; Lois J Mannon; Robert I Grossman; Oded Gonen
Journal:  AJNR Am J Neuroradiol       Date:  2003-01       Impact factor: 3.825

9.  Novel composite MRI scale correlates highly with disability in multiple sclerosis patients.

Authors:  Peter Kosa; Mika Komori; Ryan Waters; Tianxia Wu; Irene Cortese; Joan Ohayon; Kaylan Fenton; Jamie Cherup; Tomas Gedeon; Bibiana Bielekova
Journal:  Mult Scler Relat Disord       Date:  2015-08-28       Impact factor: 4.339

10.  Tissue-specific imaging is a robust methodology to differentiate in vivo T1 black holes with advanced multiple sclerosis-induced damage.

Authors:  M Riva; V N Ikonomidou; J J Ostuni; P van Gelderen; S Auh; J M Ohayon; F Tovar-Moll; N D Richert; J H Duyn; F Bagnato
Journal:  AJNR Am J Neuroradiol       Date:  2009-04-30       Impact factor: 3.825
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