BACKGROUND: In acute meningitis hyponatremia is common and traditionally attributed exclusively to inappropriate water retention. However, the exact mechanisms underlying hyponatremia are unknown. METHODS: The files of 300 pediatric patients with acute bacterial (n = 190) or aseptic (n = 110) meningitides were retrospectively analyzed. RESULTS: The plasma sodium level ranged from 122 to 148 mmol/l and was low (<133 mmol/l) in 97 patients. Fluid volume contraction was significantly more pronounced in hyponatremia (median 6.0. 10(-2)) than in normonatremia (median 2.0. 10(-2)). The fractional sodium excretion was less than 1.00. 10(-2) in the 26 hyponatremic children with this measurement. CONCLUSION: In acute meningitis hyponatremia is not exclusively brought about by inappropriate water retention. Copyright 2001 S. Karger AG, Basel
BACKGROUND: In acute meningitis hyponatremia is common and traditionally attributed exclusively to inappropriate water retention. However, the exact mechanisms underlying hyponatremia are unknown. METHODS: The files of 300 pediatric patients with acute bacterial (n = 190) or aseptic (n = 110) meningitides were retrospectively analyzed. RESULTS: The plasma sodium level ranged from 122 to 148 mmol/l and was low (<133 mmol/l) in 97 patients. Fluid volume contraction was significantly more pronounced in hyponatremia (median 6.0. 10(-2)) than in normonatremia (median 2.0. 10(-2)). The fractional sodium excretion was less than 1.00. 10(-2) in the 26 hyponatremic children with this measurement. CONCLUSION: In acute meningitis hyponatremia is not exclusively brought about by inappropriate water retention. Copyright 2001 S. Karger AG, Basel
Authors: Alberto Bettinelli; Laura Longoni; Fabiana Tammaro; Pietro B Faré; Luca Garzoni; Mario G Bianchetti Journal: Pediatr Nephrol Date: 2012-01-12 Impact factor: 3.714
Authors: Mattia Peruzzo; Gregorio P Milani; Luca Garzoni; Laura Longoni; Giacomo D Simonetti; Alberto Bettinelli; Emilio F Fossali; Mario G Bianchetti Journal: Ital J Pediatr Date: 2010-12-13 Impact factor: 2.638