Literature DB >> 11358492

Regulation of p53 localization.

S H Liang1, M F Clarke.   

Abstract

Despite intensive study of p53, the regulation of p53 cellular localization is still poorly understood. This is an overview of the elements and molecules involved in p53 nucleocytoplasmic transportation. These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2-mediated p53 nuclear export, and possible roles of p53 phosphorylation in regulating p53 cellular localization. Finally, questions regarding p53 cellular trafficking will also be discussed.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11358492     DOI： 10.1046/j.1432-1327.2001.02227.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  59 in total

1.  Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.

Authors:  Hiroyuki Takai; Kazuhito Naka; Yuki Okada; Miho Watanabe; Naoki Harada; Shin'ichi Saito; Carl W Anderson; Ettore Appella; Makoto Nakanishi; Hiroshi Suzuki; Kazuo Nagashima; Hirofumi Sawa; Kyoji Ikeda; Noboru Motoyama
Journal:  EMBO J       Date:  2002-10-01       Impact factor: 11.598

2.  Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.

Authors:  Xiaosheng Wu; Jeffrey L Platt; Marilia Cascalho
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

3.  p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines.

Authors:  Junfang Ji; Kun Wu; Min Wu; Qimin Zhan
Journal:  Front Med China       Date:  2010-12-30

4.  A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.

Authors:  R Swanson; M Locher; M Hochstrasser
Journal:  Genes Dev       Date:  2001-10-15       Impact factor: 11.361

5.  Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.

Authors:  Maria Rosario Fernandez-Fernandez; Dmitry B Veprintsev; Alan R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-21       Impact factor: 11.205

6.  Allelic loss at TP53 in metastatic human endometrial carcinomas.

Authors:  Wiktor Szewczuk; Danuta Skomra; Marek Cybulski; Dorota Przadka-Rabaniuk; Agata Filip; Maciej Jóźwik; Piotr Olcha; Albert Roessner; Andrzej Semczuk
Journal:  Clin Exp Metastasis       Date:  2009-06-30       Impact factor: 5.150

7.  Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion.

Authors:  G Renuka Kumar; Leona Shum; Britt A Glaunsinger
Journal:  Mol Cell Biol       Date:  2011-06-06       Impact factor: 4.272

8.  Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage.

Authors:  Xin Cai; Xuan Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-24       Impact factor: 11.205

9.  Mitochondrial matrix P53 sensitizes cells to oxidative stress.

Authors:  Christopher A Koczor; Rebecca A Torres; Earl J Fields; Amy Boyd; William Lewis
Journal:  Mitochondrion       Date:  2013-03-14       Impact factor: 4.160

Review 10.  Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity.

Authors:  Huferesh Darbary; Daniel L Stoler; Garth R Anderson
Journal:  Surg Oncol Clin N Am       Date:  2009-01       Impact factor: 3.495
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.