Literature DB >> 11356688

Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation.

D S Johnston1, L D Russell, P J Friel, M D Griswold.   

Abstract

The spermatogonial stem cell transplantation technique was employed to determine if murine germ cells require functional androgen receptors to complete qualitatively normal spermatogenesis. Testicular cells from testicular feminized mice were injected into the seminiferous tubules of azoospermic mice expressing functional androgen receptors. Recipient testes were analyzed between 110 and 200 days following transplantation. Multiple colonies of complete and qualitatively normal donor-derived spermatogenesis were seen within the seminiferous tubules of each recipient testis, demonstrating that murine germ cells do not require functional androgen receptors to complete spermatogenesis.

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Year:  2001        PMID： 11356688     DOI： 10.1210/endo.142.6.8317

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  35 in total

Review 1.  Germline stem cell transplantation and transgenesis.

Authors:  Ralph L Brinster
Journal:  Science       Date:  2002-06-21       Impact factor: 47.728

Review 2.  The key role of vitamin A in spermatogenesis.

Authors:  Cathryn A Hogarth; Michael D Griswold
Journal:  J Clin Invest       Date:  2010-04-01       Impact factor: 14.808

Review 3.  Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone.

Authors:  Suresh Ramaswamy; Gerhard F Weinbauer
Journal:  Spermatogenesis       Date:  2015-01-26

Review 4.  The Sertoli cell: one hundred fifty years of beauty and plasticity.

Authors:  L R França; R A Hess; J M Dufour; M C Hofmann; M D Griswold
Journal:  Andrology       Date:  2016-02-04       Impact factor: 3.842

Review 5.  Transgenic models for exploring gonadotropin biology in the male.

Authors:  Charles M Allan; David J Handelsman
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

6.  Testosterone signaling and the regulation of spermatogenesis.

Authors:  William H Walker
Journal:  Spermatogenesis       Date:  2011-04

Review 7.  Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice.

Authors:  Ruey-Sheng Wang; Shuyuan Yeh; Chii-Ruey Tzeng; Chawnshang Chang
Journal:  Endocr Rev       Date:  2009-01-27       Impact factor: 19.871

Review 8.  Androgens and spermatogenesis: lessons from transgenic mouse models.

Authors:  Guido Verhoeven; Ariane Willems; Evi Denolet; Johannes V Swinnen; Karel De Gendt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-05-27       Impact factor: 6.237

9.  Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

Authors:  Ariane Willems; Sergio R Batlouni; Arantza Esnal; Johannes V Swinnen; Philippa T K Saunders; Richard M Sharpe; Luiz R França; Karel De Gendt; Guido Verhoeven
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

10.  Androgen action via testicular peritubular myoid cells is essential for male fertility.

Authors:  Michelle Welsh; Philippa T K Saunders; Nina Atanassova; Richard M Sharpe; Lee B Smith
Journal:  FASEB J       Date:  2009-08-19       Impact factor: 5.191
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