F Benazzi1. 1. Department of Psychiatry, National Health Service (A.USL), P. Solieri 4, 47100 Forlì, Italy. f.benazzi@fo.nettuno.it
Abstract
BACKGROUND: Depressive mixed states (major depressive episodes with some hypomanic symptoms) (DMS) are not classified in DSM-IV and are understudied. The aims of this study were to find the prevalence and clinical features of DMS in atypical depression. METHODS: A total of 87 bipolar II and unipolar depressed outpatients were interviewed within the DSM-IV Structured Clinical Interview. RESULTS: More than two hypomanic symptoms were present in 50.0% of the atypical and 20.3% of the non-atypical depression cases (P=0.006). DMS mainly included irritable mood, distractibility, racing thoughts, and increased talking. LIMITATIONS: There was a single interviewer, and it was a non-blind, cross-sectional assessment, with bipolar II reliability. CONCLUSIONS: Findings have treatment implications, as antidepressants may worsen DMS, and mood stabilizers may improve it.
BACKGROUND:Depressive mixed states (major depressive episodes with some hypomanic symptoms) (DMS) are not classified in DSM-IV and are understudied. The aims of this study were to find the prevalence and clinical features of DMS in atypical depression. METHODS: A total of 87 bipolar II and unipolar depressed outpatients were interviewed within the DSM-IV Structured Clinical Interview. RESULTS: More than two hypomanic symptoms were present in 50.0% of the atypical and 20.3% of the non-atypical depression cases (P=0.006). DMS mainly included irritable mood, distractibility, racing thoughts, and increased talking. LIMITATIONS: There was a single interviewer, and it was a non-blind, cross-sectional assessment, with bipolar II reliability. CONCLUSIONS: Findings have treatment implications, as antidepressants may worsen DMS, and mood stabilizers may improve it.
Authors: Andrés Herane-Vives; Danilo Arnone; Valeria de Angel; Andrew Papadopoulos; Toby Wise; Luis Alameda; Kia-Chong Chua; Allan H Young; Anthony J Cleare Journal: Int J Bipolar Disord Date: 2020-03-05
Authors: Katia M'Bailara; Donatienne Van den Bulke; Nicolas Demazeau; Jacques Demotes-Mainard; Chantal Henry Journal: Neuropsychiatr Dis Treat Date: 2007-12 Impact factor: 2.570