Literature DB >> 11356163

Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.

S Eaton1, K Fukumoto, N Paladio Duran, A Pierro, L Spitz, P A Quant, K Bartlett.   

Abstract

Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11356163     DOI： 10.1042/0300-5127:0290245

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  6 in total

1.  Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze.

Authors:  Vijay Sharma; John H McNeill
Journal:  World J Cardiol       Date:  2011-09-26

2.  Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles.

Authors:  Edwin R Price; James F Staples; C Louise Milligan; Christopher G Guglielmo
Journal:  J Comp Physiol B       Date:  2010-12-14       Impact factor: 2.200

3.  The hypotriglyceridemic effect of dietary n-3 FA is associated with increased beta-oxidation and reduced leptin expression.

Authors:  J Ukropec; J E Reseland; D Gasperikova; E Demcakova; L Madsen; R K Berge; A C Rustan; I Klimes; C A Drevon; E Sebökova
Journal:  Lipids       Date:  2003-10       Impact factor: 1.880

Review 4.  Metabolism as a complex genetic trait, a systems biology approach: implications for inborn errors of metabolism and clinical diseases.

Authors:  Jerry Vockley
Journal:  J Inherit Metab Dis       Date:  2008-10-05       Impact factor: 4.982

5.  Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer's disease in vitro model.

Authors:  Sandra I Mota; Inês Pita; Rodolfo Águas; Slah Tagorti; Ashraf Virmani; Frederico C Pereira; A Cristina Rego
Journal:  Arch Toxicol       Date:  2021-06-24       Impact factor: 5.153

Review 6.  Acylcarnitines: reflecting or inflicting insulin resistance?

Authors:  Marieke G Schooneman; Frédéric M Vaz; Sander M Houten; Maarten R Soeters
Journal:  Diabetes       Date:  2013-01       Impact factor: 9.461
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.