Literature DB >> 11355956

Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation.

H K Roy1, W J Karoski, A Ratashak, T C Smyrk.   

Abstract

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. Copyright 2001 Cancer Research Campaign.

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Year:  2001        PMID： 11355956      PMCID： PMC2363636          DOI： 10.1054/bjoc.2001.1807

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  22 in total

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Authors:  L Zhang; J Yu; B H Park; K W Kinzler; B Vogelstein
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Review 2.  Chemoprevention of colorectal cancer.

Authors:  P A Jänne; R J Mayer
Journal:  N Engl J Med       Date:  2000-06-29       Impact factor: 91.245

Review 3.  The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis.

Authors:  D C Chung
Journal:  Gastroenterology       Date:  2000-09       Impact factor: 22.682

4.  Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

Authors:  S K Boolbol; A J Dannenberg; A Chadburn; C Martucci; X J Guo; J T Ramonetti; M Abreu-Goris; H L Newmark; M L Lipkin; J J DeCosse; M M Bertagnolli
Journal:  Cancer Res       Date:  1996-06-01       Impact factor: 12.701

Review 5.  Bcl-2 family: life-or-death switch.

Authors:  Y Tsujimoto; S Shimizu
Journal:  FEBS Lett       Date:  2000-01-21       Impact factor: 4.124

6.  M30 expression demonstrates apoptotic cells, correlates with in situ end-labeling, and is associated with Ki-67 expression in large intestinal neoplasms.

Authors:  N J Carr
Journal:  Arch Pathol Lab Med       Date:  2000-12       Impact factor: 5.534

7.  Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance.

Authors:  G B Baretton; J Diebold; G Christoforis; M Vogt; C Müller; K Dopfer; K Schneiderbanger; M Schmidt; U Löhrs
Journal:  Cancer       Date:  1996-01-15       Impact factor: 6.860

8.  Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam.

Authors:  H K Roy; M Bissonnette; B P Frawley; R K Wali; S M Niedziela; D Earnest; T A Brasitus
Journal:  FEBS Lett       Date:  1995-06-12       Impact factor: 4.124

9.  Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

Authors:  P C Chulada; M B Thompson; J F Mahler; C M Doyle; B W Gaul; C Lee; H F Tiano; S G Morham; O Smithies; R Langenbach
Journal:  Cancer Res       Date:  2000-09-01       Impact factor: 12.701

10.  Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.

Authors:  C Bombardier; L Laine; A Reicin; D Shapiro; R Burgos-Vargas; B Davis; R Day; M B Ferraz; C J Hawkey; M C Hochberg; T K Kvien; T J Schnitzer
Journal:  N Engl J Med       Date:  2000-11-23       Impact factor: 91.245
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  2 in total

1.  Increased microvascular blood content is an early event in colon carcinogenesis.

Authors:  R K Wali; H K Roy; Y L Kim; Y Liu; J L Koetsier; D P Kunte; M J Goldberg; V Turzhitsky; V Backman
Journal:  Gut       Date:  2005-05       Impact factor: 23.059

Review 2.  Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience.

Authors:  Takashi Fujimura; Tetsuo Ohta; Katsunobu Oyama; Tomoharu Miyashita; Koichi Miwa
Journal:  World J Gastroenterol       Date:  2006-03-07       Impact factor: 5.742
  2 in total

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