Literature DB >> 11354380

Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists.

K Kikuchi1, K Tagami, S Hibi, H Yoshimura, N Tokuhara, K Tai, T Hida, T Yamauchi, M Nagai.   

Abstract

In the course of studies on novel retinoids, we have designed and synthesized a series of quinoline derivatives. One of them, 4-[5-[8-(1-methylethyl)-4-phenyl-2-quinolinyl]-1H-2-pyrrolyl]benzoic acid (12f) shows potent RARalpha-selective antagonistic activity.

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Year:  2001        PMID： 11354380     DOI： 10.1016/s0960-894x(01)00177-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.

Authors:  Alberto García-Mariscal; Karine Peyrollier; Astrid Basse; Esben Pedersen; Ralph Rühl; Jolanda van Hengel; Cord Brakebusch
Journal:  Small GTPases       Date:  2016-11-16

2.  Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.

Authors:  Mingqiang Ren; Silvia Pozzi; Gaia Bistulfi; Giulia Somenzi; Stefano Rossetti; Nicoletta Sacchi
Journal:  Mol Cell Biol       Date:  2005-12       Impact factor: 4.272

3.  Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.

Authors:  Floriana Centritto; Gabriela Paroni; Marco Bolis; Silvio Ken Garattini; Mami Kurosaki; Maria Monica Barzago; Adriana Zanetti; James Neil Fisher; Mark Francis Scott; Linda Pattini; Monica Lupi; Paolo Ubezio; Francesca Piccotti; Alberto Zambelli; Paola Rizzo; Maurizio Gianni'; Maddalena Fratelli; Mineko Terao; Enrico Garattini
Journal:  EMBO Mol Med       Date:  2015-07       Impact factor: 12.137

4.  Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.

Authors:  Francesca Corlazzoli; Stefano Rossetti; Gaia Bistulfi; Mingqiang Ren; Nicoletta Sacchi
Journal:  PLoS One       Date:  2009-02-04       Impact factor: 3.240

5.  Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.

Authors:  Giulia Somenzi; Giusy Sala; Stefano Rossetti; MingQiang Ren; Riccardo Ghidoni; Nicoletta Sacchi
Journal:  PLoS One       Date:  2007-09-05       Impact factor: 3.240
  5 in total

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