Literature DB >> 11354375

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

Y Xia1, Z Y Yang, M J Hour, S C Kuo, P Xia, K F Bastow, Y Nakanishi, P Namrpoothiri, T Hackl, E Hamel, H K Lee.   

Abstract

A series of 2',3',4',6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the asopharynx.

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Year:  2001        PMID： 11354375     DOI： 10.1016/s0960-894x(01)00190-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

1.  Identification of novel inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase by chemical screening in Arabidopsis thaliana.

Authors:  Lee-Chung Lin; Jen-Hung Hsu; Long-Chi Wang
Journal:  J Biol Chem       Date:  2010-08-03       Impact factor: 5.157

2.  Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.

Authors:  Rajesh Karuturi; Rami A Al-Horani; Shrenik C Mehta; David Gailani; Umesh R Desai
Journal:  J Med Chem       Date:  2013-03-18       Impact factor: 7.446

3.  Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones.

Authors:  Yong Jin Kim; Eun Ae Kim; Mi Lyang Chung; Chaeuk Im
Journal:  Korean J Physiol Pharmacol       Date:  2009-12-31       Impact factor: 2.016

4.  Methyl 2-(2-hydroxy-acetamido)benzoate.

Authors:  Samina Alam; Sadaf Saeed; Andreas Fischer; Naeema Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-24

5.  Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

Authors:  Yu-Hsun Chang; Mei-Hua Hsu; Sheng-Hung Wang; Li-Jiau Huang; Keduo Qian; Susan L Morris-Natschke; Ernest Hamel; Sheng-Chu Kuo; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

6.  Diversity-oriented synthesis of benzimidazole, benzoxazole, benzothiazole and quinazolin-4(3H)-one libraries via potassium persulfate-CuSO4-mediated oxidative coupling reactions of aldehydes in aqueous micelles.

Authors:  Atul Kumar; Ram Awatar Maurya; Deepti Saxena
Journal:  Mol Divers       Date:  2009-07-04       Impact factor: 2.943

7.  Synthesis of new 4(3H)-quinazolinone derivatives using 5(4H)-oxazolones.

Authors:  Hooshang Hamidian; Ahmad Momeni Tikdari; Hojatollah Khabazzadeh
Journal:  Molecules       Date:  2006-05-27       Impact factor: 4.411

8.  A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative.

Authors:  Nimalini Devi Moirangthem; Warjeet Singh Laitonjam
Journal:  Beilstein J Org Chem       Date:  2010-11-09       Impact factor: 2.883

9.  New 6-Bromo-2-Methyl-3-(Substituted Phenyl)-(3H)-Quinazolin-4-Ones with Antimicrobial and Antiinflammatory Activities.

Authors:  Y Murti; A K Singh; D Pathak
Journal:  Indian J Pharm Sci       Date:  2011-05       Impact factor: 0.975

10.  Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives.

Authors:  G A Khodarahmi; M Rahmani Khajouei; G H Hakimelahi; D Abedi; E Jafari; F Hassanzadeh
Journal:  Res Pharm Sci       Date:  2012-07
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