Literature DB >> 11354374

NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines.

J Oiry1, P Mialocq, J Y Puy, P Fretier, P Clayette, D Dormont, J L Imbach.   

Abstract

I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases.

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Year:  2001        PMID： 11354374     DOI： 10.1016/s0960-894x(01)00171-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine.

Authors:  Rita Crinelli; Carolina Zara; Michaël Smietana; Michele Retini; Mauro Magnani; Alessandra Fraternale
Journal:  Nutrients       Date:  2019-06-07       Impact factor: 5.717

2.  Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.

Authors:  Alessandra Fraternale; Rita Crinelli; Anna Casabianca; Maria Filomena Paoletti; Chiara Orlandi; Elisa Carloni; Michaël Smietana; Anna Teresa Palamara; Mauro Magnani
Journal:  PLoS One       Date:  2013-03-11       Impact factor: 3.240

3.  The Dual Effects of Reactive Oxygen Species on the Mandibular Alveolar Bone Formation in SOD1 Knockout Mice: Promotion or Inhibition.

Authors:  Yunyan Zhang; Yuzhi Yang; Mingxue Xu; Jingwen Zheng; Yuchan Xu; Guoqing Chen; Qiang Guo; Weidong Tian; Weihua Guo
Journal:  Oxid Med Cell Longev       Date:  2021-02-03       Impact factor: 6.543
  3 in total

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