Literature DB >> 11354371

Synthesis and evaluation of efavirenz (Sustiva) analogues as HIV-1 reverse transcriptase inhibitors: replacement of the cyclopropylacetylene side chain.

A J Cocuzza1, D R Chidester, B C Cordova, S Jeffrey, R L Parsons, L T Bacheler, S Erickson-Viitanen, G L Trainor, S S Ko.   

Abstract

Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the entire acetylenic side chain has been replaced by alkyloxy groups. Several members of both series show equivalent potency to efavirenz against both wild-type virus and the key K103N mutant.

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Year:  2001        PMID： 11354371     DOI： 10.1016/s0960-894x(01)00192-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  One-pot solvent-free synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives using Fe3O4@nano-cellulose/TiCl as a bio-based and recyclable magnetic nano-catalyst.

Authors:  Sara Azad; Bi Bi Fatemeh Mirjalili
Journal:  Mol Divers       Date:  2018-10-12       Impact factor: 2.943

2.  One-pot synthesis of naphtho[1,2-e][1,3]oxazines in the presence of FNAOSiPAMP*/CuII as an almond shell based nanocatalyst.

Authors:  Mina Keihanfar; Bi Bi Fatemeh Mirjalili
Journal:  Sci Rep       Date:  2022-10-21       Impact factor: 4.996

3.  Redox-neutral α-oxygenation of amines: reaction development and elucidation of the mechanism.

Authors:  Matthew T Richers; Martin Breugst; Alena Yu Platonova; Anja Ullrich; Arne Dieckmann; K N Houk; Daniel Seidel
Journal:  J Am Chem Soc       Date:  2014-04-14       Impact factor: 15.419

4.  Synthesis and Fungicidal Activity of 1-(Carbamoylmethyl)-2-aryl-3,1-benzoxazines.

Authors:  Zi-Long Tang; Lian Wang; Jing-Zhao Tan; Yi-Chao Wan; Yin-Chun Jiao
Journal:  Molecules       Date:  2017-07-06       Impact factor: 4.411

5.  Gum arabic-OPO3H2 as a new natural-based green catalyst for the one-pot pseudo-four-component synthesis of naphtho[1,2-e][1,3]oxazines.

Authors:  Sahar Saadat Hosseinikhah; Bi Bi Fatemeh Mirjalili; Naeimeh Salehi; Abdolahamid Bamoniri
Journal:  RSC Adv       Date:  2020-11-06       Impact factor: 4.036

6.  Synthesis of meso-substituted dihydro-1,3-oxazinoporphyrins.

Authors:  Satyasheel Sharma; Mahendra Nath
Journal:  Beilstein J Org Chem       Date:  2013-03-07       Impact factor: 2.883
  6 in total

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