Literature DB >> 11354363

1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.

R G Sherrill1, J M Berman, L Birkemo, D K Croom, M Dezube, G N Ervin, M K Grizzle, M K James, M F Johnson, K L Queen, T J Rimele, F Vanmiddlesworth, E E Sugg.   

Abstract

A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.

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Year:  2001        PMID： 11354363     DOI： 10.1016/s0960-894x(01)00164-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.

Authors:  Aditya J Desai; Brad R Henke; Laurence J Miller
Journal:  Bioorg Med Chem Lett       Date:  2015-03-24       Impact factor: 2.823

Review 2.  Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor.

Authors:  A J Desai; M Dong; K G Harikumar; L J Miller
Journal:  Int J Obes Suppl       Date:  2016-11-16

3.  Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity.

Authors:  Daniela G Dengler; Qing Sun; Kaleeckal G Harikumar; Laurence J Miller; Eduard A Sergienko
Journal:  SLAS Discov       Date:  2022-07-16       Impact factor: 3.341

4.  Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?

Authors:  Jennie Ho; Jeremy M Cox; Edward J Wagner
Journal:  Physiol Behav       Date:  2007-04-29

5.  A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.

Authors:  Aditya J Desai; Kaleeckal G Harikumar; Laurence J Miller
Journal:  J Biol Chem       Date:  2014-05-13       Impact factor: 5.157

Review 6.  Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics.

Authors:  Laurence J Miller; Kaleeckal G Harikumar; Denise Wootten; Patrick M Sexton
Journal:  Front Endocrinol (Lausanne)       Date:  2021-06-02       Impact factor: 5.555
  6 in total

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