| Literature DB >> 1135429 |
M O Pulkkinen, Y Pitkanen, A Ojala, H Hannelin.
Abstract
Pregnancy had been terminated in 6 normal midtrimester pregnant patients by the extraovular injection of 10 mg prostaglandin F2alpha (PGF2alpha). In these 6 Experimental and 3 Control patients utero-placental blood flow had been measured, by changes in the density of radioactive Indium, distributed over the uterine area, as a function of time. In comparison with Controls utero-placental blood flow decreased in the Experimental patients already at 5 minutes after PG-treatment, long before advanced cyclic IUP evolved. This finding substantiates the conclusion (1-3), based on experiments in animal "models', that decrease in utero-placental blood flow is an early step in the mechanism of PG action.Entities:
Keywords: Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Biology; Comparative Studies; Endocrine System; Family Planning; Fertility Control, Postconception; Physiology; Prostaglandins--pharmacodynamics; Research Methodology; Studies
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Year: 1975 PMID： 1135429 DOI： 10.1016/s0090-6980(75)80117-1
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980