Literature DB >> 11353657

Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa.

K Tateda1, R Comte, J C Pechere, T Köhler, K Yamaguchi, C Van Delden.   

Abstract

We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

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Year:  2001        PMID： 11353657      PMCID： PMC90577          DOI： 10.1128/AAC.45.6.1930-1933.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa.

Authors:  H Wu; Z Song; M Hentzer; J B Andersen; A Heydorn; K Mathee; C Moser; L Eberl; S Molin; N Høiby; M Givskov
Journal:  Microbiology       Date:  2000-10       Impact factor: 2.777

2.  Long-term azithromycin may improve lung function in children with cystic fibrosis.

Authors:  A Jaffé; J Francis; M Rosenthal; A Bush
Journal:  Lancet       Date:  1998-02-07       Impact factor: 79.321

Review 3.  Macrolides for the treatment of Pseudomonas aeruginosa infections?

Authors:  R A Howe; R C Spencer
Journal:  J Antimicrob Chemother       Date:  1997-08       Impact factor: 5.790

4.  Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes.

Authors:  J P Pearson; E C Pesci; B H Iglewski
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

5.  Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms.

Authors:  P K Singh; A L Schaefer; M R Parsek; T O Moninger; M J Welsh; E P Greenberg
Journal:  Nature       Date:  2000-10-12       Impact factor: 49.962

6.  'Subinhibitory' erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and virulence factors.

Authors:  D Sofer; N Gilboa-Garber; A Belz; N C Garber
Journal:  Chemotherapy       Date:  1999 Sep-Oct       Impact factor: 2.544

7.  The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity.

Authors:  G Telford; D Wheeler; P Williams; P T Tomkins; P Appleby; H Sewell; G S Stewart; B W Bycroft; D I Pritchard
Journal:  Infect Immun       Date:  1998-01       Impact factor: 3.441

8.  Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant.

Authors:  C Van Delden; E C Pesci; J P Pearson; B H Iglewski
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

9.  Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis.

Authors:  O Geisenberger; M Givskov; K Riedel; N Høiby; B Tümmler; L Eberl
Journal:  FEMS Microbiol Lett       Date:  2000-03-15       Impact factor: 2.742

Review 10.  Cell-to-cell signaling and Pseudomonas aeruginosa infections.

Authors:  C Van Delden; B H Iglewski
Journal:  Emerg Infect Dis       Date:  1998 Oct-Dec       Impact factor: 6.883
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  106 in total

1.  The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils.

Authors:  Kazuhiro Tateda; Yoshikazu Ishii; Manabu Horikawa; Tetsuya Matsumoto; Shinichi Miyairi; Jean Claude Pechere; Theodore J Standiford; Masaji Ishiguro; Keizo Yamaguchi
Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441

Review 2.  Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

Authors:  David Brown
Journal:  Nat Rev Drug Discov       Date:  2015-10-23       Impact factor: 84.694

3.  Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.

Authors:  Xiangping Zeng; Xiangyang Liu; Jiang Bian; Gang Pei; Huanqin Dai; Steven W Polyak; Fuhang Song; Li Ma; Yuqiang Wang; Lixin Zhang
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

4.  Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis.

Authors:  Paul Beringer; Kitty My Tu Huynh; Jane Kriengkauykiat; Luke Bi; Nils Hoem; Stan Louie; Emily Han; Thao Nguyen; Donald Hsu; Purush A Rao; Bertrand Shapiro; Mark Gill
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

5.  Two novel synthetic peptides inhibit quorum sensing-dependent biofilm formation and some virulence factors in Pseudomonas aeruginosa PAO1.

Authors:  Mostafa N Taha; Amal E Saafan; A Ahmedy; Eman El Gebaly; Ahmed S Khairalla
Journal:  J Microbiol       Date:  2019-06-27       Impact factor: 3.422

Review 6.  Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.

Authors:  Morten Hentzer; Michael Givskov
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

7.  Ribosome protection prevents azithromycin-mediated quorum-sensing modulation and stationary-phase killing of Pseudomonas aeruginosa.

Authors:  Thilo Köhler; Jean-Luc Dumas; Christian Van Delden
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

8.  Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Authors:  Zackery P Bulman; Mark D Sutton; Neang S Ly; Jurgen B Bulitta; Patricia N Holden; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

9.  Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis.

Authors:  Jiro Nakayama; Emi Tanaka; Reiko Kariyama; Koji Nagata; Kenzo Nishiguchi; Ritsuko Mitsuhata; Yumi Uemura; Masaru Tanokura; Hiromi Kumon; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-10-27       Impact factor: 3.490

Review 10.  Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Authors:  Hemang Yadav; Steve G Peters; Karina A Keogh; William J Hogan; Patricia J Erwin; Colin P West; Cassie C Kennedy
Journal:  Biol Blood Marrow Transplant       Date:  2016-08-26       Impact factor: 5.742
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