Literature DB >> 11353650

Azasordarins: susceptibility of fluconazole-susceptible and fluconazole-resistant clinical isolates of Candida spp. to GW 471558.

M Cuenca-Estrella1, E Mellado, T M Díaz-Guerra, A Monzón, J L Rodríguez-Tudela.   

Abstract

The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 microg/ml).

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Year:  2001        PMID： 11353650      PMCID： PMC90570          DOI： 10.1128/AAC.45.6.1905-1907.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Comparison of a spectrophotometric microdilution method with RPMI-2% glucose with the National Committee for Clinical Laboratory Standards reference macrodilution method M27-P for in vitro susceptibility testing of amphotericin B, flucytosine, and fluconazole against Candida albicans.

Authors:  J L Rodríguez-Tudela; J Berenguer; J V Martínez-Suárez; R Sanchez
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

2.  Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.

Authors:  J M Domínguez; V A Kelly; O S Kinsman; M S Marriott; F Gómez de las Heras; J J Martín
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

3.  Pharmacokinetics-pharmacodynamics of a sordarin derivative (GM 237354) in a murine model of lethal candidiasis.

Authors:  P Aviles; C Falcoz; R San Roman; D Gargallo-Viola
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

4.  Sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, Pneumocystis carinii, and filamentous fungi.

Authors:  E Herreros; C M Martinez; M J Almela; M S Marriott; F G De Las Heras; D Gargallo-Viola
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

5.  Activities of sordarins in murine histoplasmosis.

Authors:  J R Graybill; L Najvar; A Fothergill; R Bocanegra; F G de las Heras
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

6.  Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans.

Authors:  J M Domínguez; J J Martín
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191
  6 in total

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