Ultrastructure and composition of basement membranes in the tooth.

The tooth, the hardest organ in the body, is known to be formed through highly elaborate, unique processes of differentiation and development. Basement membranes play critical roles in fundamentally important biological processes such as growth and differentiation, and for better understanding of the mechanism of development and maintenance of the tooth, specializations of tooth basement membranes are reviewed in detail in relation to their roles. The basement membrane at such diverse locations in the tooth as the inner enamel epithelium, maturation-stage ameloblasts, and junctional epithelium at the dentogingival border are specialized in their own highly unique ways for anchoring, firm binding, or mediation in the transport of substances. Thus, the role of basement membranes in the developing and mature tooth is manifold and for these roles individual basement membranes are specialized in their own specific ways which are rare or not seen in nondental tissues, and these specializations are essential for successful development and maintenance of the tooth.