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Literature DB >> 11349814

The search for a new model structure of beta-factor XIIa.

E S Henriques¹, W B Floriano, N Reuter, A Melo, D Brown, J A Gomes, B Maigret, M A Nascimento, M J Ramos.

Abstract

We present the search for a new model of beta-factor XIIa, a blood coagulation enzyme, with an unknown experimental 3D-structure. We decided to build not one but three different models using different homologous proteins as well as different techniques and different modelers. Additional studies, including extensive molecular dynamics simulations on the solvated state, allowed us to draw several conclusions concerning homology modelling, in general, and beta-factor XIIa, in particular.

Entities: Disease

Mesh：

Substances：
Factor XIIa

Year: 2001 PMID： 11349814 DOI： 10.1023/a:1011128521816

Source DB: PubMed Journal: J Comput Aided Mol Des ISSN： 0920-654X Impact factor: 3.686

21 in total

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Authors: S Mosimann; R Meleshko; M N James
Journal: Proteins Date: 1995-11

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Journal: Protein Eng Date: 1990-01

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Journal: Proc Natl Acad Sci U S A Date: 1988-04 Impact factor: 11.205

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Authors: S D Revak; C G Cochrane; A R Johnston; T E Hugli
Journal: J Clin Invest Date: 1974-09 Impact factor: 14.808

5. Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

Authors: D E Cool; C J Edgell; G V Louie; M J Zoller; G D Brayer; R T MacGillivray
Journal: J Biol Chem Date: 1985-11-05 Impact factor: 5.157

Review 6. The molecular basis of blood coagulation.

Authors: B Furie; B C Furie
Journal: Cell Date: 1988-05-20 Impact factor: 41.582

7. Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region.

Authors: D E Cool; R T MacGillivray
Journal: J Biol Chem Date: 1987-10-05 Impact factor: 5.157

3. Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation.

Authors: B K Hamad; M Pathak; R Manna; P M Fischer; J Emsley; L V Dekker
Journal: J Thromb Haemost Date: 2017-08-09 Impact factor: 5.824

3 in total

The search for a new model structure of beta-factor XIIa.

1. A critical assessment of comparative molecular modeling of tertiary structures of proteins.

2. Construction of validated, non-redundant composite protein sequence databases.

3. Improved tools for biological sequence comparison.

4. Structural changes accompanying enzymatic activation of human Hageman factor.

5. Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

Review 6. The molecular basis of blood coagulation.

7. Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region.

8. A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server.

9. Human factor XII (Hageman factor).

10. Amino acid sequence of human beta-factor XIIa.

1. On the modeling of snake venom serine proteinase interactions with benzamidine-based thrombin inhibitors.

2. Drug design for ever, from hype to hope.

3. Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation.