Three-dimensional analysis of eye movements during off vertical axis rotation in patients with unilateral labyrinthine loss.

3D analysis of eye movements during off vertical axis rotation (OVAR) was carried out in seven subjects with unilateral labyrinthine loss (ULL). The modulation component (MOC) of these patients was not different from that of normal subjects. However, the horizontal MOC was significantly smaller when the rotation was directed towards the diseased side as opposed to the healthy side. With rotation to the diseased side, most subjects exhibited a horizontal bias component (BIC) to the opposite side as compared with the diseased side in normal subjects. The vertical and torsional BICs were also influenced to some extent by lack of input from the unilateral labyrinth. These results indicate that a unilateral otolith organ plays a major role in the production of the horizontal BIC contralateral to the direction of rotation, which is strongly related to the velocity storage mechanism in the central nervous system. In addition, the unilateral otolith organ exerts some influence on the generation of the horizontal MOC and also the BIC of vertical and torsional eye movements.