The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: an experimental study in mice.

In this experimental study on mice we try to prove that capsule formation around breast implants is considerably diminished after topical application of Mitomycin-C (MMC). MMC solution is applied under the breast tissue or pectoralis major muscle, in the pocket of the silicone implant and just before placing it. This is a morphological study of the connective tissue formed around the implant, under light and electron microscope. Our results suggest that it is worthwhile working on a clinical study trying to prevent the most common complication of breast implants, contracture of a capsule.