Literature DB >> 11349094

gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization.

K J McGovern1, T G Blanchard, J A Gutierrez, S J Czinn, S Krakowka, P Youngman.   

Abstract

The contribution of glutamyl transpeptidase (GGT) (gamma-glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.

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Year:  2001        PMID： 11349094      PMCID： PMC98487          DOI： 10.1128/IAI.69.6.4168-4173.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  37 in total

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Authors:  H Suzuki; H Kumagai; T Echigo; T Tochikura
Journal:  J Bacteriol       Date:  1989-09       Impact factor: 3.490

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Authors:  B J Marshall; J R Warren
Journal:  Lancet       Date:  1984-06-16       Impact factor: 79.321

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Authors:  A Meister; S S Tate; O W Griffith
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

4.  Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice.

Authors:  C Chevalier; J M Thiberge; R L Ferrero; A Labigne
Journal:  Mol Microbiol       Date:  1999-03       Impact factor: 3.501

5.  Nucleotide sequence of the kanamycin resistance transposon Tn903.

Authors:  A Oka; H Sugisaki; M Takanami
Journal:  J Mol Biol       Date:  1981-04-05       Impact factor: 5.469

6.  Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content.

Authors:  F Megraud; F Bonnet; M Garnier; H Lamouliatte
Journal:  J Clin Microbiol       Date:  1985-12       Impact factor: 5.948

7.  Naturally occurring chronic gastritis and C pylori infection in the rhesus monkey: a potential model for gastritis in man.

Authors:  A Baskerville; D G Newell
Journal:  Gut       Date:  1988-04       Impact factor: 23.059

8.  Campylobacter pylori isolated from the stomach of the monkey, Macaca nemestrina.

Authors:  M A Bronsdon; F D Schoenknecht
Journal:  J Clin Microbiol       Date:  1988-09       Impact factor: 5.948

9.  Campylobacter pylori virulence factors in gnotobiotic piglets.

Authors:  K A Eaton; D R Morgan; S Krakowka
Journal:  Infect Immun       Date:  1989-04       Impact factor: 3.441

10.  Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet.

Authors:  S Krakowka; D R Morgan; W G Kraft; R D Leunk
Journal:  Infect Immun       Date:  1987-11       Impact factor: 3.441
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  38 in total

1.  Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori.

Authors:  Dirk Bumann; Sevil Aksu; Meike Wendland; Katharina Janek; Uschi Zimny-Arndt; Nicolas Sabarth; Thomas F Meyer; Peter R Jungblut
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441

2.  Detailed analysis of Helicobacter pylori Fur-regulated promoters reveals a Fur box core sequence and novel Fur-regulated genes.

Authors:  Oscar Q Pich; Beth M Carpenter; Jeremy J Gilbreath; D Scott Merrell
Journal:  Mol Microbiol       Date:  2012-05-14       Impact factor: 3.501

3.  A gonococcal homologue of meningococcal gamma-glutamyl transpeptidase gene is a new type of bacterial pseudogene that is transcriptionally active but phenotypically silent.

Authors:  Hideyuki Takahashi; Haruo Watanabe
Journal:  BMC Microbiol       Date:  2005-10-04       Impact factor: 3.605

4.  Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.

Authors:  Vinayak Kapatral; Iain Anderson; Natalia Ivanova; Gary Reznik; Tamara Los; Athanasios Lykidis; Anamitra Bhattacharyya; Allen Bartman; Warren Gardner; Galina Grechkin; Lihua Zhu; Olga Vasieva; Lien Chu; Yakov Kogan; Oleg Chaga; Eugene Goltsman; Axel Bernal; Niels Larsen; Mark D'Souza; Theresa Walunas; Gordon Pusch; Robert Haselkorn; Michael Fonstein; Nikos Kyrpides; Ross Overbeek
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

Review 5.  Structural and functional aspects of the Helicobacter pylori secretome.

Authors:  Giuseppe Zanotti; Laura Cendron
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

6.  Campylobacter jejuni host tissue tropism: a consequence of its low-carb lifestyle?

Authors:  Stuart A Thompson; Erin C Gaynor
Journal:  Cell Host Microbe       Date:  2008-11-13       Impact factor: 21.023

Review 7.  Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role.

Authors:  Vittorio Ricci; Maria Giannouli; Marco Romano; Raffaele Zarrilli
Journal:  World J Gastroenterol       Date:  2014-01-21       Impact factor: 5.742

8.  Chronic Helicobacter pylori infection with Sydney strain 1 and a newly identified mouse-adapted strain (Sydney strain 2000) in C57BL/6 and BALB/c mice.

Authors:  Lucinda J Thompson; Stephen J Danon; John E Wilson; Jani L O'Rourke; Nina R Salama; Stanley Falkow; Hazel Mitchell; Adrian Lee
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

Review 9.  Helicobacter pylori γ-glutamyl transpeptidase: a formidable virulence factor.

Authors:  Samantha Shi Min Ling; Khay Guan Yeoh; Bow Ho
Journal:  World J Gastroenterol       Date:  2013-12-07       Impact factor: 5.742

10.  Histoplasma capsulatum secreted gamma-glutamyltransferase reduces iron by generating an efficient ferric reductant.

Authors:  Robert Zarnowski; Kendal G Cooper; Laura Schmitt Brunold; Jimmy Calaycay; Jon P Woods
Journal:  Mol Microbiol       Date:  2008-08-29       Impact factor: 3.501
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