Literature DB >> 11348713

Comparison of three different influenza vaccines in institutionalised elderly.

V Baldo1, T Menegon, C Bonello, A Floreani, R Trivello.   

Abstract

The reactogenicity and the humoral immune response to three influenza vaccines were evaluated in a randomised, double-blind trial at nursing homes in north-east Italy in winter 1998-1999. Of the 285 subjects, who completed the follow-up, 93 were administered virosomal vaccine, 99 received MF59-adjuvanted vaccine and 93 had split vaccine. Ten subjects (0.3%) reported local and/or systemic reactions in the first week after immunisation. After 4 weeks, protection rates (> or = 40) were near 100% for the H1N1 and B strain and 76.0% against H3N2. The MF59-adjuvanted vaccine group had higher geometric mean titres than the other two. However, the true clinical benefit of the new adjuvanted vaccine should be further substantiated by comparative protective studies. Our results suggest that immune response to influenza vaccination in institutionalised elderly is satisfactory.

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Year:  2001        PMID： 11348713     DOI： 10.1016/s0264-410x(01)00060-3

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  15 in total

Review 1.  Inactivated influenza vaccines: recent progress and implications for the elderly.

Authors:  Valentina Parodi; Daniela de Florentiis; Mariano Martini; Filippo Ansaldi
Journal:  Drugs Aging       Date:  2011-02-01       Impact factor: 3.923

2.  Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

Authors:  Ali H Ellebedy; Christopher Lupfer; Hazem E Ghoneim; Jennifer DeBeauchamp; Thirumala-Devi Kanneganti; Richard J Webby
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-26       Impact factor: 11.205

3.  [Conventional influenza vaccination compared to MF59 adjuvanted subunit vaccine].

Authors:  María Amparo Torrecilla Rojas; Miguel Pedregal González; Fermín García Rodriguez; Josefa Ruiz Fernández
Journal:  Aten Primaria       Date:  2009-10-02       Impact factor: 1.137

Review 4.  Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: A literature review.

Authors:  Barbara Camilloni; Michela Basileo; Stefano Valente; Emilia Nunzi; Anna Maria Iorio
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

5.  Comparative Immunogenicity of Enhanced Seasonal Influenza Vaccines in Older Adults: A Systematic Review and Meta-analysis.

Authors:  Tiffany W Y Ng; Benjamin J Cowling; Hui Zhi Gao; Mark G Thompson
Journal:  J Infect Dis       Date:  2019-04-19       Impact factor: 5.226

Review 6.  Cross-protection against drifted influenza viruses: options offered by adjuvanted and intradermal vaccines.

Authors:  Andrea Orsi; Filippo Ansaldi; Daniela de Florentiis; Antonella Ceravolo; Valentina Parodi; Paola Canepa; Martina Coppelli; Giancarlo Icardi; Paolo Durando
Journal:  Hum Vaccin Immunother       Date:  2013-01-07       Impact factor: 3.452

7.  Recommendations on the use of MF59-Adjuvanted Trivalent Influenza Vaccine (Fluad®): Supplemental Statement of Seasonal Influenza Vaccine for 2011-2012 An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI)†.

Authors: 
Journal:  Can Commun Dis Rep       Date:  2011-10-21

8.  Immunogenicity of three different influenza vaccines against homologous and heterologous strains in nursing home elderly residents.

Authors:  Vincenzo Baldo; Tatjana Baldovin; Michele Pellegrini; Gabriele Angiolelli; Silvia Majori; Annarosa Floreani; Marta Cecilia Busana; Chiara Bertoncello; Renzo Trivello
Journal:  Clin Dev Immunol       Date:  2010-03-29

9.  Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults.

Authors:  P Durando; D Fenoglio; A Boschini; F Ansaldi; G Icardi; L Sticchi; A Renzoni; P Fabbri; A Ferrera; A Parodi; B Bruzzone; G Gabutti; A Podda; G Del Giudice; E Fragapane; F Indiveri; P Crovari; R Gasparini
Journal:  Clin Vaccine Immunol       Date:  2007-11-14

10.  Response of influenza vaccines against heterovariant influenza virus strains in adults with chronic diseases.

Authors:  V Baldo; T Baldovin; A Floreani; E Fragapane; R Trivello
Journal:  J Clin Immunol       Date:  2007-05-21       Impact factor: 8.317
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