| Literature DB >> 11348710 |
L V Truoc1, H M Ly, N K Thuy, D D Trach, C A Stanford, J L Stanford.
Abstract
Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in the first 4 years of the study and 5/65 (7.7%) developed the disease in the second 4 years. In comparison with this, among those vaccinated, 20/343 (5.8%) developed leprosy in the first 4 years and 5/323 (1.5%) developed leprosy in the second 4 years. This represents 52.5% protection in the first 4 years and 80.5% in the second 4 years. There were no significant differences in protection afforded by each of the three vaccines but the success of the killed preparation of M. vaccae is an important finding.Entities:
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Year: 2001 PMID： 11348710 DOI： 10.1016/s0264-410x(01)00052-4
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641