Literature DB >> 11348243

A novel enantioselective synthetic route to omuralide analogues with the potential for species selectivity in proteasome inhibition.

S N Crane1, E J Corey.   

Abstract

[reaction in text] The building blocks shown can be combined for an enantioselective construction of the simplified omuralide analogue 4 in nine steps, with the use of (R)-atrolactic acid as a recoverable chiral controller.

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Year:  2001        PMID： 11348243     DOI： 10.1021/ol015757p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  2-Hy-droxy-11-methyl-16-[(E)-4-methyl-benzyl-idene]-13-(4-methyl-phen-yl)-1,11-diaza-penta-cyclo-[12.3.1.0.0.0]octa-deca-3(8),4,6-triene-9,15-dione.

Authors:  Raju Suresh Kumar; Hasnah Osman; Mohamed Ashraf Ali; Chin Sing Yeap; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-08-21

2.  Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.

Authors:  Jiang Yin; Ernst M Bergmann; Maia M Cherney; Manjinder S Lall; Rajendra P Jain; John C Vederas; Michael N G James
Journal:  J Mol Biol       Date:  2005-10-14       Impact factor: 5.469
  2 in total

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