Literature DB >> 11345192

Role of Jak kinases and STATs in cytokine signal transduction.

W J Leonard1.   

Abstract

The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after activation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.

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Year:  2001        PMID： 11345192     DOI： 10.1007/BF02981951

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.319


  50 in total

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6.  Partial impairment of cytokine responses in Tyk2-deficient mice.

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  61 in total

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Review 6.  Opposing functions of IL-2 and IL-7 in the regulation of immune responses.

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9.  Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.

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