Increasing threat of Gram-positive bacterial infections in the intensive care unit setting.

The effects of resistance are being noted on an increasing scale in the intensive care unit (ICU). Around the world, new epidemiologic patterns of ICU occurrence are being observed for Gram-positive multidrug-resistant organisms. Current problems include the appearance of insusceptibility to vancomycin and other glycopeptides in Staphylococcus aureus organisms that are virulent enough to cause infection in patients with normal host defenses. In addition, multidrug-resistant organisms like methicillin-resistant S.aureus are spreading from healthcare to community settings, and community organisms like Streptococcus pneumoniae are spreading to healthcare settings. Focal persistence and subsequent worldwide spread of enterococci resistant to vancomycin and other glycopeptides and multiple-resistance mechanisms in the same organism also require attention. Strategies such as multidisciplinary management of infections, appropriate infection control measures, and surveillance of resistance patterns are necessary to address the problem of resistance. Intensivists have been prominent in research and control efforts in this field and should continue to lead future efforts.