Literature DB >> 11344978

The use of becaplermin (rhPDGF-BB) gel for chronic nonhealing ulcers. A retrospective analysis.

V J Mandracchia1, S M Sanders, J A Frerichs.   

Abstract

Chronic, nonhealing wounds have plagued health care practitioners for decades. New research and technology have allowed the wound healing process to be understood at a cellular and molecular level, including the vital role of growth factors. This article discusses the effects of platelet-derived growth factor-BB (PDGF-BB) on the wound healing process, emphasizing the inflammatory stage of wound healing and principles of wound care. Preclinical and clinical studies evaluating recombinant human PDGF-BB (rhPDGF-BB) (becaplermin gel) also are discussed. Lastly, the results of a retrospective analysis evaluating the use of rhPDGF-BB at Broadlawns Medical Center (Des Moines, IA) are presented.

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Year:  2001        PMID： 11344978

Source DB:  PubMed          Journal:  Clin Podiatr Med Surg        ISSN： 0891-8422            Impact factor:   1.231


  7 in total

1.  A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

Authors:  Chieh-Fang Cheng; Divya Sahu; Fred Tsen; Zhengwei Zhao; Jianhua Fan; Rosie Kim; Xinyi Wang; Kathryn O'Brien; Yong Li; Yuting Kuang; Mei Chen; David T Woodley; Wei Li
Journal:  J Clin Invest       Date:  2011-10-24       Impact factor: 14.808

2.  Effect of recombinant human platelet-derived growth factor B on cat corneal endothelial cell viability mediated by adeno-associated virus.

Authors:  Wen-Juan Luo; Xiao-Ming Xing; Chuan-Fu Wang; Li-Ting Hu; Gui-Qiu Zhao; Xiang-Ping Liu; Kun Wu; Hui Li
Journal:  Int J Ophthalmol       Date:  2012-08-18       Impact factor: 1.779

Review 3.  Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally.

Authors:  Wei Li; Fred Tsen; Divya Sahu; Ayesha Bhatia; Mei Chen; Gabriele Multhoff; David T Woodley
Journal:  Int Rev Cell Mol Biol       Date:  2013       Impact factor: 6.813

Review 4.  Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.

Authors:  Wei Li; Divya Sahu; Fred Tsen
Journal:  Biochim Biophys Acta       Date:  2011-09-25

Review 5.  Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure.

Authors:  Ayesha Bhatia; Kathryn O'Brien; Mei Chen; David T Woodley; Wei Li
Journal:  Adv Wound Care (New Rochelle)       Date:  2016-04-01       Impact factor: 4.730

Review 6.  Cutaneous wound healing: recruiting developmental pathways for regeneration.

Authors:  Kirsten A Bielefeld; Saeid Amini-Nik; Benjamin A Alman
Journal:  Cell Mol Life Sci       Date:  2012-10-04       Impact factor: 9.261

Review 7.  Wound Healing Driver Gene and Therapeutic Development: Political and Scientific Hurdles.

Authors:  Xin Tang; Michelle Hao; Cheng Chang; Ayesha Bhatia; Kathrine O'Brien; Mei Chen; David G Armstrong; Wei Li
Journal:  Adv Wound Care (New Rochelle)       Date:  2020-10-28       Impact factor: 4.947
  7 in total

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