| Literature DB >> 11343742 |
A W Horne1, J O White, R A Margara, R Williams, R M Winston, E Lalani.
Abstract
In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2.5 kb compared with 3.4 kb in the fertile group (p=0.0029, difference 0.9, [95% CI 0.1-1.3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.Entities:
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Year: 2001 PMID： 11343742 DOI： 10.1016/s0140-6736(00)04502-5
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321