BACKGROUND: Prior studies using simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks. METHODS: Event-related potentials of 66 patients (14 unmedicated) diagnosed with schizophrenia (n = 46) or schizoaffective disorder (n = 20) and 32 healthy adults were recorded from 30 scalp electrodes during two oddball tasks using consonant-vowel syllables or complex tones. Overlapping ERP components were identified and measured by covariance-based principal components analysis. RESULTS: Schizophrenic patients showed marked, task-independent reductions of early negative potentials (N1, N2) but not reduced P3 amplitude or abnormal P3 asymmetry. Task-related hemispheric asymmetries of the N2/P3 complex were similar in healthy adults and schizophrenic patients. Poorer task performance in patients was related to ERP amplitudes, but could not account for reductions of early negativities. CONCLUSIONS: The findings suggest that both patients and control subjects activated lateralized cortical networks required for pitch (right frontotemporal) and phoneme (left parietotemporal) discrimination. Task-independent reductions of negativities between 80 and 280 msec after stimulus onset suggest a deficit of automatic stimulus classification in schizophrenia, which may be partly compensated by later effortful processing.
BACKGROUND: Prior studies using simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks. METHODS: Event-related potentials of 66 patients (14 unmedicated) diagnosed with schizophrenia (n = 46) or schizoaffective disorder (n = 20) and 32 healthy adults were recorded from 30 scalp electrodes during two oddball tasks using consonant-vowel syllables or complex tones. Overlapping ERP components were identified and measured by covariance-based principal components analysis. RESULTS:Schizophrenicpatients showed marked, task-independent reductions of early negative potentials (N1, N2) but not reduced P3 amplitude or abnormal P3 asymmetry. Task-related hemispheric asymmetries of the N2/P3 complex were similar in healthy adults and schizophrenicpatients. Poorer task performance in patients was related to ERP amplitudes, but could not account for reductions of early negativities. CONCLUSIONS: The findings suggest that both patients and control subjects activated lateralized cortical networks required for pitch (right frontotemporal) and phoneme (left parietotemporal) discrimination. Task-independent reductions of negativities between 80 and 280 msec after stimulus onset suggest a deficit of automatic stimulus classification in schizophrenia, which may be partly compensated by later effortful processing.
Authors: Jürgen Kayser; Craig E Tenke; Dolores Malaspina; Christopher J Kroppmann; Jennifer D Schaller; Andrew Deptula; Nathan A Gates; Jill M Harkavy-Friedman; Roberto Gil; Gerard E Bruder Journal: Psychophysiology Date: 2010-11 Impact factor: 4.016
Authors: Jürgen Kayser; Craig E Tenke; Christopher J Kroppmann; Daniel M Alschuler; Shiva Fekri; Roberto Gil; L Fredrik Jarskog; Jill M Harkavy-Friedman; Gerard E Bruder Journal: Psychophysiology Date: 2012-07-16 Impact factor: 4.016
Authors: Jürgen Kayser; Craig E Tenke; Christopher J Kroppmann; Shiva Fekri; Daniel M Alschuler; Nathan A Gates; Roberto Gil; Jill M Harkavy-Friedman; Lars F Jarskog; Gerard E Bruder Journal: Int J Psychophysiol Date: 2009-12-06 Impact factor: 2.997
Authors: Sarah M Haigh; Rebecca M Laher; Timothy K Murphy; Brian A Coffman; Kayla L Ward; Justin R Leiter-McBeth; Lori L Holt; Dean F Salisbury Journal: Schizophr Res Date: 2019-04-11 Impact factor: 4.939