Literature DB >> 11343389

Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms.

A R Tabrizi1, S D McGrath, M A Blinder, T G Buchman, B A Zehnbauer, B D Freeman.   

Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication. Copyright 2001 Wiley-Liss, Inc.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11343389     DOI： 10.1002/ajh.1094

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  4 in total

1.  Extreme sensitivity to acenocoumarol therapy in patient with both VKORC.-1639 A/A and CYP2C9*1/*3 genotypes.

Authors:  Mirjana K Kovac; Ljiljana B Rakicevic; Dragica P Radojkovic
Journal:  J Thromb Thrombolysis       Date:  2011-10       Impact factor: 2.300

Review 2.  Warfarin reversal.

Authors:  J P Hanley
Journal:  J Clin Pathol       Date:  2004-11       Impact factor: 3.411

Review 3.  Polymorphism induced sensitivity to warfarin: a review of the literature.

Authors:  Michael P Palkimas; Hillary M Skinner; Pritesh J Gandhi; Alice J Gardner
Journal:  J Thromb Thrombolysis       Date:  2003-06       Impact factor: 2.300

Review 4.  Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine.

Authors:  Shabbir Ahmed; Zhan Zhou; Jie Zhou; Shu-Qing Chen
Journal:  Genomics Proteomics Bioinformatics       Date:  2016-10-08       Impact factor: 7.691
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.