Literature DB >> 11342698

A favorable response to antiparkinsonian treatment in juvenile neuronal ceroid lipofuscinosis.

L E Aberg1, J O Rinne, I Rajantie, P Santavuori.   

Abstract

To study the effect of dopaminergic drugs on the parkinsonism in juvenile neuronal ceroid lipofuscinosis, the authors conducted an open study of 21 patients. According to the motor Unified PD Rating Scale (UPDRS) score, treatment was initiated with either levodopa (n = 10) or selegiline (n = 6). Five patients served as a control group. The UPDRS score after 1 year was compared with the score at onset. Both in the control group and in the selegiline group, the mean UPDRS score increased, whereas in the levodopa group, the mean UPDRS score decreased. The difference between the levodopa group and the control group was significant.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11342698     DOI： 10.1212/wnl.56.9.1236

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  7 in total

Review 1.  Juvenile parkinsonism: epidemiology, diagnosis and treatment.

Authors:  Teri R Thomsen; Robert L Rodnitzky
Journal:  CNS Drugs       Date:  2010-06       Impact factor: 5.749

2.  Clinical trials in rare disease: challenges and opportunities.

Authors:  Erika F Augustine; Heather R Adams; Jonathan W Mink
Journal:  J Child Neurol       Date:  2013-09       Impact factor: 1.987

Review 3.  Neuronal ceroid lipofuscinosis: impact of recent genetic advances and expansion of the clinicopathologic spectrum.

Authors:  Susan L Cotman; Amel Karaa; John F Staropoli; Katherine B Sims
Journal:  Curr Neurol Neurosci Rep       Date:  2013-08       Impact factor: 5.081

Review 4.  Juvenile neuronal ceroid lipofuscinosis (JNCL) and the eye.

Authors:  Sara Bozorg; Denia Ramirez-Montealegre; Mina Chung; David A Pearce
Journal:  Surv Ophthalmol       Date:  2009 Jul-Aug       Impact factor: 6.048

5.  Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Authors:  Jill M Weimer; Jared W Benedict; Yasser M Elshatory; Douglas W Short; Denia Ramirez-Montealegre; Deborah A Ryan; Noreen A Alexander; Howard J Federoff; Jonathan D Cooper; David A Pearce
Journal:  Brain Res       Date:  2007-05-21       Impact factor: 3.252

Review 6.  Juvenile neuronal ceroid lipofuscinosis (Batten disease): current insights.

Authors:  John R Ostergaard
Journal:  Degener Neurol Neuromuscul Dis       Date:  2016-08-01

Review 7.  Neurodegenerative Disease Risk in Carriers of Autosomal Recessive Disease.

Authors:  Sophia R L Vieira; Huw R Morris
Journal:  Front Neurol       Date:  2021-06-04       Impact factor: 4.003
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.